From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
CautionEmerging evidence
What is happening. Rhodiola is promoted for stimulant and monoaminergic effects. Combining it with MAO-B inhibition may increase agitation, insomnia, blood pressure, or serotonergic symptoms.
Mechanism. Possible additive monoaminergic stimulation with impaired monoamine metabolism.
Recommendation. Avoid unless the prescriber specifically approves; monitor blood pressure and neuropsychiatric symptoms if exposure has already occurred.
Stack Score
How it moves the number.
Effect on the composite score
If both Rhodiola Rosea and Selegiline are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1U.S. National Library of Medicine. Selegiline hydrochloride capsules US Prescribing Information. 2025.Needs sourceNo link