Interaction databaseSupplement × SupplementReviewed May 2026

Tribulus Terrestris and Zinc, a synergy.

Zinc is an essential cofactor for testosterone synthesis, so correcting low zinc status complements the libido-supporting use of Tribulus in male reproductive health.

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances
Tribulus Terrestris and Zinc
Pair type
Synergy
Evidence (highest tier)
Emerging
Source citations
2 sources
Stack Score effect
+2 to your Stack Score (per scored synergy row).
Scope
Supplement × Supplement
Last verified
May 30, 2026

Synergy · Emerging evidence

Synergy

What is happening. Zinc is an essential cofactor for testosterone synthesis, so correcting low zinc status complements the libido-supporting use of Tribulus in male reproductive health.

Mechanism. Zinc is required for testicular steroidogenesis and luteinizing hormone signaling, so adequate zinc supports the hormonal substrate while Tribulus acts on libido and nitric oxide pathways.

Recommendation. Reasonable combination for male reproductive support. Avoid chronic high-dose zinc above 40 mg daily to prevent copper depletion.

Sources (2)
  1. Prasad AS et al, Zinc status and serum testosterone levels of healthy adults, Nutrition, 1996
  2. Neychev V, Mitev V, Pro-sexual and androgen enhancing effects of Tribulus terrestris, Journal of Ethnopharmacology, 2016

Stack Score

How this pair moves the number.

Effect on the composite score

If both Tribulus Terrestris and Zinc are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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