NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated July 13, 2026

Amoxicillin

Prescription ·Exploratory record · not publication-reviewed ·Updated July 13, 2026

A broad-spectrum penicillin antibiotic used to treat a wide variety of bacterial infections including otitis media, sinusitis, pharyngitis, lower respiratory tract infections, urinary tract infections, and H. pylori eradication (in combination). It is one of the most commonly prescribed antibiotics worldwide due to its favorable safety profile and efficacy against many gram-positive and some gram-negative organisms.

Evidence tier
Strong
Indexed sources
10 1998–2024
Interactions
0
Depletes
1 nutrient
Read the sources → Compare profiles
Publication status

Exploratory record, not a reviewed medical publication.

See the editorial and medical-review policies for the publication gate.

This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.

In short

What the research says.

A quick, data-only summary. The full evidence, dosing, and sources are below.

A broad-spectrum penicillin antibiotic used to treat a wide variety of bacterial infections including otitis media, sinusitis, pharyngitis, lower respiratory tract infections, urinary tract infections, and H. NutriStack rates the supporting evidence as strong. Common adult dosing is 250-500 mg every 8 hours or 500-875 mg every 12 hours; high-dose 1000 mg TID for resistant organisms (as prescribed by your physician), though a prescriber sets the actual dose. With long-term use it can deplete vitamin k. This profile indexes 10 sources.

What it's good for
  • Treats streptococcal pharyngitis (strep throat)8
  • Treats acute otitis media10,6
  • Treats acute bacterial sinusitis6,9
  • Treats community-acquired pneumonia
  • H. pylori eradication (combination therapy)2,4
What to watch for
  • Diarrhea
  • Nausea and vomiting
  • Skin rash (maculopapular, especially with EBV infection)
  • Known penicillin or beta-lactam allergy
  • History of anaphylaxis to amoxicillin or any penicillin1,2

The bottom line

Evidence rating strong. Most-documented uses: treats streptococcal pharyngitis (strep throat), treats acute otitis media, treats acute bacterial sinusitis. 10 sources indexed (1998–2024), with 0 interaction records on file.

The science

How it works, mechanistically.

Core mechanism

Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), which are transpeptidases essential for cross-linking peptidoglycan in the bacterial cell wall. This prevents the final transpeptidation step, weakening the cell wall and leading to osmotic lysis and bacterial death. Amoxicillin is bactericidal and effective against actively dividing organisms.9

Class
Penicillin Antibiotic
Dosing

Dosing & protocol.

Common range
250-500 mg every 8 hours or 500-875 mg every 12 hours; high-dose 1000 mg TID for resistant organisms (as prescribed by your physician)
Recommended form
Oral capsules, tablets, or suspension

Well absorbed orally (~90% bioavailability) regardless of food. Can be taken with or without food; food does not significantly affect absorption.5

Depletions

What it depletes.

Nutrients this medication can lower over time, and what to replace.

Vitamin K

Mild

Broad-spectrum antibiotic exposure can suppress gut bacteria that synthesize menaquinones, lowering vitamin K availability in susceptible patients.

Monitor PT/INROnset Usually with prolonged therapy, poor intake, or malabsorption

Full Amoxicillin depletion and interaction guide →

Safety

Full safety detail.

Side effects

  • Diarrhea
  • Nausea and vomiting
  • Skin rash (maculopapular, especially with EBV infection)
  • Allergic reactions (urticaria, anaphylaxis in penicillin-allergic patients)
  • Vaginal candidiasis
  • Clostridioides difficile-associated diarrhea

Contraindications

  • Known penicillin or beta-lactam allergy
  • History of anaphylaxis to amoxicillin or any penicillin1,2
  • Infectious mononucleosis (high risk of maculopapular rash)
  • History of cholestatic jaundice/hepatic dysfunction with amoxicillin use
Sources

Sources, by evidence tier.

Numbered references. Citations throughout the page link here.

Meta-analyses & systematic reviews

6

Randomized controlled trials

1

Reference material

3
FAQ

Common questions.

Quick answers about Amoxicillin, drawn from the data on this page.

What is Amoxicillin?

A broad-spectrum penicillin antibiotic used to treat a wide variety of bacterial infections including otitis media, sinusitis, pharyngitis, lower respiratory tract infections, urinary tract infections, and H. pylori eradication (in combination). It is one of the most commonly prescribed antibiotics worldwide due to its favorable safety profile and efficacy against many gram-positive and some gram-negative organisms.

What is Amoxicillin used for?

Commonly cited benefits of Amoxicillin include: Treats streptococcal pharyngitis (strep throat); Treats acute otitis media; Treats acute bacterial sinusitis; Treats community-acquired pneumonia; H. pylori eradication (combination therapy). NutriStack rates the overall evidence as strong.

What is a typical dose of Amoxicillin?

A typical adult dose of Amoxicillin is 250-500 mg every 8 hours or 500-875 mg every 12 hours; high-dose 1000 mg TID for resistant organisms (as prescribed by your physician). The commonly recommended form is Oral capsules, tablets, or suspension. These are general ranges, not personalized advice; confirm the right dose with a clinician.

What are the side effects of Amoxicillin?

Reported side effects include diarrhea, nausea and vomiting, skin rash (maculopapular, especially with ebv infection), allergic reactions (urticaria, anaphylaxis in penicillin-allergic patients), vaginal candidiasis, clostridioides difficile-associated diarrhea. This is educational information; check with a healthcare professional before use.

How strong is the evidence for Amoxicillin?

NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.

Use this with your stack

Amoxicillin in NutriStack.

Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.

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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.