NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated July 13, 2026

Duloxetine

Prescription ·Exploratory record · not publication-reviewed ·Updated July 13, 2026

Prescription serotonin-norepinephrine reuptake inhibitor (SNRI) approved for major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain. Its dual indication for mood and pain disorders makes it particularly useful for patients with comorbid depression and chronic pain syndromes. Dosage must be determined by your prescribing physician.

Evidence tier
Strong
Indexed sources
10 2019–2023
Interactions
0
Depletes
1 nutrient
Read the sources → Compare profiles
Publication status

Exploratory record, not a reviewed medical publication.

See the editorial and medical-review policies for the publication gate.

This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.

In short

What the research says.

A quick, data-only summary. The full evidence, dosing, and sources are below.

Prescription serotonin-norepinephrine reuptake inhibitor (SNRI) approved for major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain. NutriStack rates the supporting evidence as strong. Common adult dosing is 30–120 mg daily (as prescribed by your physician), though a prescriber sets the actual dose. With long-term use it can deplete sodium. This profile indexes 10 sources.

What it's good for
  • Depression symptom relief
  • Anxiety reduction
  • Neuropathic pain relief4,1
  • Fibromyalgia pain improvement1,9
  • Chronic musculoskeletal pain reduction3,9
What to watch for
  • Nausea
  • Dry mouth
  • Constipation
  • Concurrent MAOI use (within 14 days)
  • Uncontrolled narrow-angle glaucoma

The bottom line

Evidence rating strong. Most-documented uses: depression symptom relief, anxiety reduction, neuropathic pain relief. 10 sources indexed (2019–2023), with 0 interaction records on file.

The science

How it works, mechanistically.

Core mechanism

Potently inhibits the reuptake of both serotonin (5-HT) and norepinephrine (NE) by blocking SERT and NET. The balanced dual reuptake inhibition at therapeutic doses contributes to antidepressant, anxiolytic, and analgesic effects through descending pain inhibitory pathways.1

Class
SNRI
Dosing

Dosing & protocol.

Common range
30–120 mg daily (as prescribed by your physician)
Recommended form
Delayed-release capsule

Can be taken with or without food. Swallow capsules whole; do not crush, chew, or open. Avoid heavy alcohol use due to increased hepatotoxicity risk.1

Depletions

What it depletes.

Nutrients this medication can lower over time, and what to replace.

Sodium

Moderate

Antidepressant-associated SIADH can increase renal free-water retention and dilute serum sodium, producing hyponatremia.

Monitor Serum sodiumOnset Often within the first 2 to 4 weeks; can occur later

Full Duloxetine depletion and interaction guide →

Safety

Full safety detail.

Side effects

  • Nausea
  • Dry mouth
  • Constipation
  • Fatigue
  • Decreased appetite
  • Dizziness
  • Sexual dysfunction
  • Increased sweating
  • Elevated blood pressure

Contraindications

  • Concurrent MAOI use (within 14 days)
  • Uncontrolled narrow-angle glaucoma
  • Significant hepatic impairment
  • Severe renal impairment (CrCl <30 mL/min)
  • Chronic heavy alcohol use3,9
Sources

Sources, by evidence tier.

Numbered references. Citations throughout the page link here.

Meta-analyses & systematic reviews

7

Reference material

3
FAQ

Common questions.

Quick answers about Duloxetine, drawn from the data on this page.

What is Duloxetine?

Prescription serotonin-norepinephrine reuptake inhibitor (SNRI) approved for major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain. Its dual indication for mood and pain disorders makes it particularly useful for patients with comorbid depression and chronic pain syndromes. Dosage must be determined by your prescribing physician.

What is Duloxetine used for?

Commonly cited benefits of Duloxetine include: Depression symptom relief; Anxiety reduction; Neuropathic pain relief; Fibromyalgia pain improvement; Chronic musculoskeletal pain reduction. NutriStack rates the overall evidence as strong.

What is a typical dose of Duloxetine?

A typical adult dose of Duloxetine is 30–120 mg daily (as prescribed by your physician). The commonly recommended form is Delayed-release capsule. These are general ranges, not personalized advice; confirm the right dose with a clinician.

What are the side effects of Duloxetine?

Reported side effects include nausea, dry mouth, constipation, fatigue, decreased appetite, dizziness. This is educational information; check with a healthcare professional before use.

How strong is the evidence for Duloxetine?

NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.

Use this with your stack

Duloxetine in NutriStack.

Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.

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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.