NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated July 13, 2026

Rosuvastatin

Prescription ·Exploratory record · not publication-reviewed ·Updated July 13, 2026

Rosuvastatin is a high-intensity statin and one of the most potent agents for lowering LDL cholesterol. The JUPITER trial demonstrated its benefit in primary prevention among patients with elevated high-sensitivity C-reactive protein even without hyperlipidemia.

Evidence tier
Strong
Indexed sources
12 2021–2025
Interactions
0
Depletes
1 nutrient
Read the sources → Compare profiles
Publication status

Exploratory record, not a reviewed medical publication.

See the editorial and medical-review policies for the publication gate.

This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.

In short

What the research says.

A quick, data-only summary. The full evidence, dosing, and sources are below.

Rosuvastatin is a high-intensity statin and one of the most potent agents for lowering LDL cholesterol. NutriStack rates the supporting evidence as strong. Common adult dosing is 5–40 mg once daily (as prescribed by your physician), though a prescriber sets the actual dose. With long-term use it can deplete coq10. This profile indexes 12 sources.

What it's good for
  • Lowers LDL cholesterol by 45–63%9,11
  • Reduces cardiovascular events in primary and secondary prevention4,7
  • Raises HDL cholesterol modestly9,11
  • Reduces triglycerides
What to watch for
  • Myalgia and muscle pain
  • Headache
  • Nausea and abdominal pain
  • Active liver disease or unexplained persistent transaminase elevations7
  • Pregnancy and breastfeeding

The bottom line

Evidence rating strong. Most-documented uses: lowers ldl cholesterol by 45–63%, reduces cardiovascular events in primary and secondary prevention, raises hdl cholesterol modestly. 12 sources indexed (2021–2025), with 0 interaction records on file.

The science

How it works, mechanistically.

Core mechanism

Selectively and competitively inhibits HMG-CoA reductase in the liver. Rosuvastatin is hydrophilic with high hepatic selectivity, resulting in potent LDL-C reduction with relatively lower systemic muscle exposure. Upregulates hepatic LDL receptors, increases LDL clearance, and reduces VLDL synthesis.2,3

Class
HMG-CoA Reductase Inhibitor (Statin)
Dosing

Dosing & protocol.

Common range
5–40 mg once daily (as prescribed by your physician)
Recommended form
Oral tablet

Can be taken with or without food at any time of day; hydrophilic statin not dependent on CYP3A4 metabolism3

Depletions

What it depletes.

Nutrients this medication can lower over time, and what to replace.

CoQ10

Moderate

HMG-CoA reductase inhibition reduces mevalonate pathway flux, lowering endogenous CoQ10 synthesis alongside cholesterol synthesis.

Replace Coenzyme Q10 UbiquinolMonitor Plasma CoQ10Onset Often develops over weeks to months of continuous therapy

Full Rosuvastatin depletion and interaction guide →

Safety

Full safety detail.

Side effects

  • Myalgia and muscle pain
  • Headache
  • Nausea and abdominal pain
  • Elevated liver transaminases
  • Proteinuria (at higher doses)
  • Rhabdomyolysis (rare but serious)
  • New-onset diabetes (modest increased risk)

Contraindications

  • Active liver disease or unexplained persistent transaminase elevations7
  • Pregnancy and breastfeeding
  • Hypersensitivity to rosuvastatin2,3
  • Severe renal impairment (for 40 mg dose)3
  • Concurrent cyclosporine use
Sources

Sources, by evidence tier.

Numbered references. Citations throughout the page link here.

Meta-analyses & systematic reviews

6

Randomized controlled trials

1

Reference material

5
FAQ

Common questions.

Quick answers about Rosuvastatin, drawn from the data on this page.

What is Rosuvastatin?

Rosuvastatin is a high-intensity statin and one of the most potent agents for lowering LDL cholesterol. The JUPITER trial demonstrated its benefit in primary prevention among patients with elevated high-sensitivity C-reactive protein even without hyperlipidemia.

What is Rosuvastatin used for?

Commonly cited benefits of Rosuvastatin include: Lowers LDL cholesterol by 45–63%; Reduces cardiovascular events in primary and secondary prevention; Raises HDL cholesterol modestly; Reduces triglycerides. NutriStack rates the overall evidence as strong.

What is a typical dose of Rosuvastatin?

A typical adult dose of Rosuvastatin is 5–40 mg once daily (as prescribed by your physician). The commonly recommended form is Oral tablet. These are general ranges, not personalized advice; confirm the right dose with a clinician.

What are the side effects of Rosuvastatin?

Reported side effects include myalgia and muscle pain, headache, nausea and abdominal pain, elevated liver transaminases, proteinuria (at higher doses), rhabdomyolysis (rare but serious). This is educational information; check with a healthcare professional before use.

How strong is the evidence for Rosuvastatin?

NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.

Use this with your stack

Rosuvastatin in NutriStack.

Add it to your stack, see how it interacts with everything else you take, and get a Stack Score that updates the moment it does.

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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.