NutriStack
Symptom·Stress·Reviewed May 30, 2026
Supplements for Adrenal stress / wired but tired.
When adrenal stress / wired but tired is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01AshwagandhaModerate86% match
An adaptogen that may attenuate HPA-axis reactivity and lower serum cortisol, which could ease the wired-but-tired pattern.
SuggestedStandardized root extract (KSM-66 or Sensoril, withanolides) - 02Rhodiola RoseaModerate79% match
An adaptogen thought to modulate stress-response signaling and central monoamines, which may reduce stress-related fatigue.
SuggestedStandardized extract (3 percent rosavins, 1 percent salidroside) - 03Magnesium GlycinateModerate72% match
May support neuromuscular relaxation and counter stress-related magnesium depletion, easing tension and supporting sleep quality.
SuggestedMagnesium glycinate - 04Holy Basil/TulsiLimited66% match
An adaptogenic herb that may blunt the cortisol response to stress and support a calmer baseline, though human data remain limited.
SuggestedStandardized Ocimum tenuiflorum leaf extract - 05PhosphatidylserineLimited62% match
A membrane phospholipid that may dampen the cortisol response to acute and exercise-related stress.
SuggestedSunflower-derived phosphatidylserine - 06Vitamin CLimited58% match
Concentrated in the adrenal glands and used in catecholamine synthesis, so adequacy supports the physical stress response, though supplementation above sufficiency shows little added benefit.
SuggestedBuffered ascorbate or ascorbic acid - 07Vitamin B5Limited54% match
As a precursor to coenzyme A, pantothenic acid participates in adrenal steroidogenesis, though clinical benefit for stress is unproven.
SuggestedCalcium pantothenate (pantothenic acid)
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