Symptom·Energy·Reviewed June 4, 2026
Supplements for Fatigue.
When fatigue is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01Nicotinamide RibosideLimited60% match
Nicotinamide riboside is an NAD+ precursor that is converted via NRK1/NRK2 kinases to NMN and then NAD+. NAD+ is an obligatory coenzyme for the electron-transport-chain dehydrogenases (NADH feeding Complex I) and for the citric-acid-cycle...
SuggestedNicotinamide riboside chloride (Niagen) 300-500 mg once daily, taken in the morning - 02MitoQ (Mitoquinone)Limited50% match
MitoQ accumulates several-hundred-fold within the inner mitochondrial membrane, where it cycles between ubiquinone and ubiquinol forms to scavenge reactive oxygen species at the site of generation. By limiting oxidative damage to electron-...
SuggestedOral mitoquinol mesylate capsule (commonly 10 mg once daily) - 03Panax GinsengLimited50% match
Ginsenosides may improve mitochondrial function and reduce oxidative stress, and ginseng has been studied for cancer-related and chronic fatigue with some reduction in self-reported fatigue scores.
SuggestedStandardized root extract, about 1,000 to 2,000 mg daily for fatigue indications - 04Oligonol (Lychee Polyphenol)Limited40% match
Small studies suggest Oligonol may reduce markers of oxidative stress and post-exertional fatigue, possibly via improved microcirculation and lower inflammatory cytokine activity, though the effect on subjective energy is modest.
SuggestedStandardized lychee polyphenol capsule, 100-200 mg/day
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These rankings come from the same library that powers the NutriStack app. Open any supplement for full dosing, forms, interactions, and citations.