NutriStack
Symptom·Energy·Reviewed May 30, 2026
Supplements for Chronic fatigue syndrome / ME support.
When chronic fatigue syndrome / me support is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01Coenzyme Q10Limited82% match
CoQ10 is a mitochondrial electron transport carrier involved in cellular ATP production, and small trials suggest it may modestly ease fatigue in ME/CFS.
SuggestedUbiquinol softgel, 100 to 200 mg daily with a fat-containing meal - 02Acetyl-L-CarnitineLimited74% match
Acetyl-L-Carnitine helps shuttle fatty acids into mitochondria for energy and may modestly improve mental and physical fatigue in some studies, though results are mixed.
SuggestedAcetyl-L-Carnitine capsule, 500 to 1000 mg once or twice daily - 03MethylcobalaminModerate68% match
Methylcobalamin is the active form of vitamin B12 needed for methylation and red blood cell formation, and correcting low B12 can reduce fatigue.
SuggestedSublingual methylcobalamin, 1000 mcg daily - 04Magnesium MalateLimited64% match
Magnesium is a cofactor for ATP-dependent reactions and the malate component feeds the Krebs cycle, which may support energy metabolism mainly when intake is low.
SuggestedMagnesium malate capsule providing 200 to 300 mg elemental magnesium daily - 05Alpha-Lipoic AcidLimited58% match
Alpha-Lipoic Acid is a mitochondrial cofactor and antioxidant that may theoretically offset oxidative stress proposed to contribute to ME/CFS fatigue.
SuggestedR-Alpha-Lipoic Acid capsule, 300 to 600 mg daily on an empty stomach - 06NMNLimited55% match
NMN is an NAD+ precursor, and because low NAD+ has been proposed in fatigue states it may theoretically support mitochondrial energy production.
SuggestedNMN capsule or sublingual, 250 to 500 mg in the morning
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