Symptom·Energy·Reviewed June 4, 2026
Supplements for General fatigue.
When general fatigue is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01ErgothioneineLimited35% match
As a mitochondrially-accumulating antioxidant, ergothioneine may reduce oxidative stress that contributes to cellular fatigue; lower levels track with frailty in older adults. There is no direct trial evidence that supplementation raises e...
SuggestedPurified L-ergothioneine capsule
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These rankings come from the same library that powers the NutriStack app. Open any supplement for full dosing, forms, interactions, and citations.