NutriStack
Symptom·Metabolic·Reviewed May 30, 2026
Supplements for Insulin resistance.
When insulin resistance is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01BerberineModerate86% match
Berberine activates AMPK to enhance glucose uptake and reduce hepatic gluconeogenesis, improving insulin sensitivity in trials of moderate quality.
SuggestedBerberine HCl (500 mg, 2 to 3 times daily with meals) - 02InositolModerate80% match
Myo- and D-chiro-inositol act as second messengers in insulin signaling and may improve insulin sensitivity, especially in PCOS-related insulin resistance.
SuggestedMyo-inositol with D-chiro-inositol (40:1 ratio) - 03Alpha-Lipoic AcidModerate72% match
ALA is a mitochondrial antioxidant that may improve insulin-stimulated glucose disposal and reduce oxidative stress that contributes to insulin resistance.
SuggestedR-alpha-lipoic acid (on an empty stomach) - 04Magnesium GlycinateModerate67% match
Magnesium is a cofactor in insulin receptor signaling and glucose transport, and correcting a deficiency can improve insulin sensitivity.
SuggestedMagnesium glycinate - 05ChromiumLimited60% match
Chromium may potentiate insulin action by supporting receptor signaling, with modest and inconsistent glycemic effects across trials.
SuggestedChromium picolinate - 06Green Tea ExtractLimited56% match
EGCG and other catechins may modestly improve glucose handling and insulin sensitivity through antioxidant and AMPK-related pathways.
SuggestedDecaffeinated green tea extract (standardized EGCG)
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These rankings come from the same library that powers the NutriStack app. Open any supplement for full dosing, forms, interactions, and citations.