NutriStack
Symptom·Cognitive·Reviewed May 30, 2026
Supplements for Sleep-deprived cognitive performance.
When sleep-deprived cognitive performance is the complaint, these are the supplements most often associated with it in the NutriStack library, ranked by how directly each one targets it and by the strength of the evidence.
Ranked by relevance, top first.
Relevance reflects how directly each supplement targets this symptom in the NutriStack map. Evidence is the supplement’s own rating. Open any name for the full profile.
- 01L-TyrosineModerate78% match
L-tyrosine is a precursor to dopamine and norepinephrine, and supplementation may help sustain working memory and cognitive flexibility under acute stressors like sleep loss.
SuggestedL-tyrosine powder or capsules, 500 to 2000 mg on an empty stomach - 02L-TheanineModerate70% match
L-theanine promotes calm alertness and, especially paired with caffeine, may improve attention and reduce the jittery downside of stimulants during fatigue.
SuggestedL-theanine capsules, 100 to 200 mg, often with caffeine - 03CiticolineLimited66% match
Citicoline supplies choline for acetylcholine synthesis and membrane phospholipids, which may support attention and processing speed.
SuggestedCiticoline (CDP-choline), 250 to 500 mg daily - 04Rhodiola RoseaLimited62% match
Rhodiola is an adaptogen that may reduce subjective fatigue and support mental performance under stress, including in studies of fatigued night-shift workers.
SuggestedStandardized extract (3 percent rosavins), 200 to 400 mg in the morning - 05Coenzyme Q10Limited55% match
CoQ10 supports mitochondrial energy production and may help counter fatigue, though direct evidence for cognition during sleep loss is lacking.
SuggestedUbiquinol softgels, 100 mg daily with a fatty meal
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These rankings come from the same library that powers the NutriStack app. Open any supplement for full dosing, forms, interactions, and citations.