NutriStack
Amlodipine and Magnesium Glycinate, a caution.
Both amlodipine and magnesium act as calcium channel blockers through related mechanisms, creating additive hypotensive effects. Amlodipine blocks L-type voltage-gated calcium channels pharmacologically, while magnesium is a physiological calcium antagonist. Oral magnesium supplements generally produce modest effects, but the combination warrants blood pressure monitoring. Intravenous magnesium with calcium channel blockers is contraindicated due to risk of severe hypotension and cardiac depression.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Amlodipine and Magnesium Glycinate
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 4 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Both amlodipine and magnesium act as calcium channel blockers through related mechanisms, creating additive hypotensive effects. Amlodipine blocks L-type voltage-gated calcium channels pharmacologically, while magnesium is a physiological calcium antagonist. Oral magnesium supplements generally produce modest effects, but the combination warrants blood pressure monitoring. Intravenous magnesium with calcium channel blockers is contraindicated due to risk of severe hypotension and cardiac depression.
Mechanism. Amlodipine inhibits calcium influx through L-type voltage-gated calcium channels in vascular smooth muscle and cardiac myocytes. Magnesium competes with calcium at these channels and also reduces intracellular calcium release. The additive calcium antagonism can produce enhanced vasodilation, hypotension, and potentially bradycardia.
Recommendation. Oral magnesium supplementation is generally safe at moderate doses (200-350 mg/day supplemental elemental magnesium) with amlodipine, but monitor blood pressure when starting. Avoid high-dose magnesium supplements. If experiencing dizziness or lightheadedness, reduce magnesium dose. Never use IV magnesium with amlodipine without medical supervision.
Sources (4)
- Koontz SL et al. Analysis of the risks associated with calcium channel blockade: implications for the obstetrician-gynecologist. Obstet Gynecol Surv. 1997;52(3):198-201. PMID 9061722
- Mah J, Pitre T. Oral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-Analysis.. BMC Complementary Medicine and Therapies. 2021. PMID 33865376
- Veronese N, Dominguez LJ, Pizzol D et al.. Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials.. Nutrients. 2021. PMID 34836329
- Veronese N, Pizzol D, Smith L et al.. Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials.. Nutrients. 2022. PMID 35277037
Stack Score
How this pair moves the number.
Effect on the composite score
If both Amlodipine and Magnesium Glycinate are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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