NutriStack
Amphetamine/Dextroamphetamine and MDMA, contraindicated.
MDMA is a substituted amphetamine with strong serotonin, norepinephrine, and dopamine releasing effects. Combining it with amphetamine/dextroamphetamine can increase stimulant toxicity, including hypertension, tachycardia, hyperthermia, dehydration, agitation, panic, and arrhythmias. Risk rises sharply with dancing or strenuous activity, hot environments, redosing, or other serotonergic or stimulant substances.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Amphetamine/Dextroamphetamine and MDMA
- Pair type
- Contraindicated
- Evidence (highest tier)
- Moderate
- Source citations
- 3 sources
- Stack Score effect
- −25 to your Stack Score (per scored contraindication row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Contraindicated · Moderate evidence
Contraindicated
What is happening. MDMA is a substituted amphetamine with strong serotonin, norepinephrine, and dopamine releasing effects. Combining it with amphetamine/dextroamphetamine can increase stimulant toxicity, including hypertension, tachycardia, hyperthermia, dehydration, agitation, panic, and arrhythmias. Risk rises sharply with dancing or strenuous activity, hot environments, redosing, or other serotonergic or stimulant substances.
Mechanism. Amphetamine/dextroamphetamine promotes dopamine and norepinephrine release through DAT and NET. MDMA releases serotonin through SERT and also releases norepinephrine and dopamine, producing overlapping adrenergic stimulation plus hyperthermia risk.
Recommendation. Do not use MDMA while taking amphetamine/dextroamphetamine. Do not redose either substance to chase effects or stay awake. Seek emergency care for high fever, confusion, severe agitation, chest pain, fainting, seizure, severe headache, or a racing or irregular heartbeat.
Sources (3)
- Green AR, Mechan AO, Elliott JM, O'Shea E, Colado MI. The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). Pharmacol Rev. 2003;55(3):463-508. PMID 12869661
- Steinkellner T, Freissmuth M, Sitte HH, Montgomery T. The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine. Biol Chem. 2011;392(1-2):103-115. PMID 21194370
- O'Cain PA, Hletko SB, Ogden BA, Varner KJ. Cardiovascular and sympathetic responses and reflex changes elicited by MDMA. Physiol Behav. 2000;70(1-2):141-148. PMID 10978489
Stack Score
How this pair moves the number.
Effect on the composite score
If both Amphetamine/Dextroamphetamine and MDMA are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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