Astaxanthin and Krill Oil: what the published research says
PubMed indexes 8 records that name Astaxanthin and Krill Oil together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.
Every statement below is attributed to a named, dated, linked source.
This page lists published research relevant to Astaxanthin and Krill Oil. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.
A study appearing here is not proof that an interaction exists. Two substances can be named together in a paper that never tested them in combination, and a source listed as background may cover only one of them.
Findings are quoted from each abstract as the authors wrote them. NutriStack has not re-analysed, pooled, or reconciled them, and they may disagree with each other.
NutriStack’s own interaction assessment for this pair is not published here. It has not completed qualified-human clinical review, so it is withheld from search. See the publication gate.
Nothing here is medical advice. Decisions about prescription medication and supplements belong with your prescriber or pharmacist, who can see your full regimen.
The research
8 studies naming Astaxanthin and Krill Oil.
Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.
“In conclusion, supplementation with KO or FO has a similar protective effect against ethanol-induced ulcer damage, as it inhibits ROS formation and reduces lipid peroxidation. However, ASX supplementation has a higher protective effect than KO or FO supplementations against experimental ethanol-induced gastric lesions in rats, as it inhibits ROS formation and reduces neutrophil infiltration and lipid peroxidation.”
Names both Astaxanthin and Krill Oil in its title.
“The resulting extract demonstrated superior antioxidant activity, which was positively correlated with its free astaxanthin content. This green and cost-effective strategy represents a promising approach for the comprehensive, high-value utilization of Antarctic krill biomass in nutraceutical and functional food applications.”
Names both Astaxanthin and Krill Oil in its title.
International journal of biological macromolecules · 2025 · PMID 40057085
Human subjects
“Furthermore, astaxanthin nanoparticles could enhance the biocompatibility of astaxanthin, and exhibited superior performance to free astaxanthin in inhibiting H2O2-induced ROS up-regulation and mitochondrial membrane potential depolarization in GES-1 cells. From the perspective of efficiency and multiple utilization of Antarctic krill resources, this study has established an innovative application of salt-soluble krill protein as a new direction of delivery materials.”
Names both Astaxanthin and Krill Oil in its title.
“All-E-astaxanthin easily transformed to the 13Z-astaxanthin than to the 9Z-astaxanthin during the drying process, but the proportions of optical isomers changed due to drying by no more than 5%. The results suggested that freeze-drying, low-power microwave drying (≤1 kW), and low-temperature hot-air drying (≤60 °C) are optimal drying methods for ensuring the quality of krill products.”
Names both Astaxanthin and Krill Oil in its title.
Journal of food science and technology · 2017 · PMID 28974791
“The changes in the a* values correlated well with the astaxanthin content in the treated krill, while the b* and L* values might relate to the browning components forming owing to Maillard reaction. The results show that free astaxanthin was less stable than crude astaxanthin under subcritical water treatment.”
Names both Astaxanthin and Krill Oil in its title.
“The fundamental "neurohormesis" principle is discussed throughout this paper. Finally, new perspectives for the application of a natural combination of the aforementioned anti-inflammatory and antioxidant agents (found in krill oil) are also presented herewith.”
Names both Astaxanthin and Krill Oil in its title.
Limitations
What this evidence cannot tell you.
Search-based evidence indexes have real limits, and it is worth being explicit about them:
Selection. These records were found by searching PubMed titles and abstracts for both substance names alongside interaction and pharmacokinetic terms. Relevant work that phrases things differently, or is not indexed in PubMed, will be missing.
No effect size. The quoted conclusions are the authors’ words about their own study. We have not extracted effect direction or magnitude, and a single study’s conclusion is not a consensus.
Population mismatch. Findings in healthy volunteers, animals, or a specific patient group may not transfer to you, your dose, or your formulation.
Absence is not safety. Few published studies means the combination is under-studied, which is not the same as established as safe.
Nearby evidence
Other pairs with published research.
Pages covering Astaxanthin or Krill Oil alongside a different substance.
NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Astaxanthin, Krill Oil, and several hundred other substances.
The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
