Supplement × Prescription·a caution·Moderate evidence
Magnesium supplements can contribute to hypermagnesemia in advanced kidney disease, and calcitriol is often used in kidney-related mineral disorders.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Magnesium supplements can contribute to hypermagnesemia in advanced kidney disease, and calcitriol is often used in kidney-related mineral disorders.
Mechanism. Reduced renal magnesium clearance plus supplemental magnesium load; calcitriol labeling warns about magnesium-containing products in dialysis.
Recommendation. Use magnesium only with clinician approval in CKD or dialysis; monitor magnesium when supplementation is necessary.
Effect on the composite score
If both Calcitriol and Magnesium Glycinate are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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