What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Cefpodoxime + Magnesium Glycinate pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Prescription·timing-sensitive·Moderate evidence

Cefpodoxime + Magnesium Glycinate

Q: Can I take Cefpodoxime and Magnesium Glycinate together?

Yes, if you separate them in time. Cefpodoxime and Magnesium Glycinate have a documented timing-sensitive interaction. Magnesium-containing supplements and antacids can reduce cefpodoxime absorption. Magnesium hydroxide antacids in particular raise gastric pH, and because cefpodoxime proxetil requires gastric acidity for dissolution, co-administration can lower antibiotic bioavailability. Magnesium glycinate is a milder, well-buffered form but the timing principle still applies during an antibiotic course.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Timing Sensitive Moderate evidence

Magnesium-containing supplements and antacids can reduce cefpodoxime absorption. Magnesium hydroxide antacids in particular raise gastric pH, and because cefpodoxime proxetil requires gastric acidity for dissolution, co-administration can lower antibiotic bioavailability. Magnesium glycinate is a milder, well-buffered form but the timing principle still applies during an antibiotic course.

Supplement × Prescription

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Cefpodoxime and Magnesium Glycinate

Pair type

Timing Sensitive

Evidence

Moderate

Source citations

Scope

Supplement × Prescription

Last verified

June 4, 2026

Timing SensitiveModerate evidence

What is happening. Magnesium-containing supplements and antacids can reduce cefpodoxime absorption. Magnesium hydroxide antacids in particular raise gastric pH, and because cefpodoxime proxetil requires gastric acidity for dissolution, co-administration can lower antibiotic bioavailability. Magnesium glycinate is a milder, well-buffered form but the timing principle still applies during an antibiotic course.

Mechanism. Antacid magnesium salts increase intragastric pH, reducing dissolution and absorption of acid-dependent cefpodoxime proxetil; divalent magnesium may also chelate beta-lactam drug in the gut lumen.

Recommendation. Separate dosing by at least 2 hours, taking cefpodoxime first. Avoid magnesium hydroxide antacids near the time of the antibiotic dose. Magnesium glycinate taken at bedtime, away from the antibiotic, is unlikely to interfere.

Timing

Timing & separation.

Space the doses apart by at least this window to avoid the conflict.

Minimum separation

120

Stack Score

How it moves the number.

Effect on the composite score

If both Cefpodoxime and Magnesium Glycinate are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Saathoff N, Lode H, Neider K, et al. Pharmacokinetics of cefpodoxime proxetil and interactions with an antacid and an H2 receptor antagonist. Antimicrob Agents Chemother. 1992.Needs sourceNo link
2Hughes GS, Heald DL, Barker KB, et al. The effects of gastric pH and food on the pharmacokinetics of a new oral cephalosporin, cefpodoxime proxetil. Clin Pharmacol Ther. 1989.Needs sourceNo link

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