NutriStack
Chlorthalidone and Magnesium Glycinate, a synergy.
Long-term chlorthalidone therapy can lower magnesium as well as potassium. Magnesium glycinate may help replace magnesium when levels are low or when low potassium is difficult to correct. Risk is higher with prolonged therapy, older age, low dietary magnesium intake, or high diuretic doses.
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At a glance
- Substances
- Chlorthalidone and Magnesium Glycinate
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Long-term chlorthalidone therapy can lower magnesium as well as potassium. Magnesium glycinate may help replace magnesium when levels are low or when low potassium is difficult to correct. Risk is higher with prolonged therapy, older age, low dietary magnesium intake, or high diuretic doses.
Mechanism. Chlorthalidone inhibits NCC in the distal convoluted tubule and can cause renal magnesium wasting over time. Magnesium glycinate provides replacement magnesium and may help stabilize potassium handling.
Recommendation. Ask for magnesium and potassium checks if you take chlorthalidone chronically. Magnesium glycinate can be reasonable for repletion, but avoid high doses without monitoring if you have kidney disease.
Sources (2)
- Cocco G, Iselin HU, Strozzi C, Cesana B, Baumeler HR. Magnesium depletion in patients on long-term chlorthalidone therapy for essential hypertension. Eur J Clin Pharmacol. 1987;32(4):335-338. PMID 2886340
- Mohn ES, Kern HJ, Saltzman E, Mitmesser SH, McKay DL. Evidence of Drug-Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update. Pharmaceutics. 2018;10(1):36. PMID 29558445
Stack Score
How this pair moves the number.
Effect on the composite score
If both Chlorthalidone and Magnesium Glycinate are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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