What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Coenzyme Q10 Ubiquinol + Rosuvastatin pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Coenzyme Q10 Ubiquinol and Rosuvastatin, a synergy.

Q: Can I take Coenzyme Q10 Ubiquinol and Rosuvastatin together?

Yes. The combination of Coenzyme Q10 Ubiquinol and Rosuvastatin produces a measurable benefit. Rosuvastatin, like all statins, inhibits the mevalonate pathway and reduces endogenous CoQ10 production. This depletion may contribute to statin-associated muscle symptoms. CoQ10 supplementation can help restore levels and may alleviate myalgia in some patients.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Rosuvastatin, like all statins, inhibits the mevalonate pathway and reduces endogenous CoQ10 production. This depletion may contribute to statin-associated muscle symptoms. CoQ10 supplementation can help restore levels and may alleviate myalgia in some patients.

2 primary source citations. Moderate evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Coenzyme Q10 Ubiquinol and Rosuvastatin
Pair type: Synergy
Evidence (highest tier): Moderate
Source citations: 2 sources
Stack Score effect: +2 to your Stack Score (per scored synergy row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Synergy · Moderate evidence

Synergy

What is happening. Rosuvastatin, like all statins, inhibits the mevalonate pathway and reduces endogenous CoQ10 production. This depletion may contribute to statin-associated muscle symptoms. CoQ10 supplementation can help restore levels and may alleviate myalgia in some patients.

Mechanism. Rosuvastatin inhibits HMG-CoA reductase in the mevalonate pathway, which supplies precursors for both cholesterol and CoQ10 synthesis. Reduced CoQ10 levels impair mitochondrial ATP production in muscle cells, potentially contributing to myalgia and myopathy.

Recommendation. Consider CoQ10 supplementation (100-200mg/day ubiquinol) if experiencing statin-related muscle symptoms. CoQ10 does not interfere with rosuvastatin's cholesterol-lowering effect.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Coenzyme Q10 Ubiquinol and Rosuvastatin are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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