Supplement researchSourced from PubMed and NIH
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Supplement × Supplement·Evidence index

Creatine and Whey Protein: what the research found

PubMed indexes 8 records that name Creatine and Whey Protein together, either in the title or in an interaction, co-administration, or pharmacokinetic context. The key findings come first, in the authors’ own words, followed by every study with its design and PubMed link.

A summary of published research, not medical advice. A pharmacist can check any combination against your full list of medicines and supplements.

Key findings

What the studies concluded.

Reviews and human studies first. Each quote is the authors’ own conclusion about their study, not a NutriStack assessment, and a single study is not a consensus.

“In conclusion, whey protein supplementation may have a positive effect in mitigating the serum CK increase induced by six consecutive days of resistance exercise.”

Kim et al. · 2026 · Human study · details

“PRO + CRE did not enhance training adaptations compared to PRO, albeit studies employing longer-term interventions with larger sample sizes are needed in order to confirm or disprove our findings.”

Wilborn et al. · 2016 · Human study · details

“Combining C, CLA, and P was beneficial for increasing strength and lean-tissue mass during heavy resistance training.”

The research

8 studies naming Creatine and Whey Protein.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Myoprotective Potential of Creatine Is Greater than Whey Protein after Chemically-Induced Damage in Rat Skeletal Muscle.

Nutrients · 2018 · PMID 29710855

Comparative StudyAnimal study

“At day 14 post-injury, CR-supplemented muscles generated higher absolute forces concomitant with greater contractile protein levels compared to CON (p = 0.001, p = 0.008) and WP-supplemented muscles (p = 0.003, p = 0.006). Creatine supplementation appears to offer an element of myoprotection which was not observed following whey protein supplementation.”

Cooke et al. · From the abstract

Names both Creatine and Whey Protein in its title.

A Pilot Study Examining the Effects of 8-Week Whey Protein versus Whey Protein Plus Creatine Supplementation on Body Composition and Performance Variables in Resistance-Trained Women.

Annals of nutrition & metabolism · 2016 · PMID 27866187

Randomized Controlled Trial

“PRO + CRE did not enhance training adaptations compared to PRO, albeit studies employing longer-term interventions with larger sample sizes are needed in order to confirm or disprove our findings.”

Wilborn et al. · Authors' conclusion

Names both Creatine and Whey Protein in its title.

The effects of creatine and whey protein supplementation on body composition in men aged 48 to 72 years during resistance training.

The journal of nutrition, health & aging · 2008 · PMID 18309444

Randomized Controlled Trial

“The results from this study suggest that supplementation with creatine, whey protein, or a combination of creatine and whey protein, when combined with resistance training in middle-aged men, have no added benefit to changes that occur to body composition due to resistance training alone.”

Eliot et al. · Authors' conclusion

Names both Creatine and Whey Protein in its title.

The effect of whey protein supplementation with and without creatine monohydrate combined with resistance training on lean tissue mass and muscle strength.

International journal of sport nutrition and exercise metabolism · 2001 · PMID 11591884

Clinical TrialRandomized Controlled Trial

“Males that supplemented with a combination of whey protein and creatine had greater increases in lean tissue mass and bench press than those who supplemented with only whey protein or placebo. However, not all strength measures were improved with supplementation, since subjects who supplemented with creatine and/or whey protein had similar increases in squat strength and knee flexion peak torque compared to subjects who received placebo.”

Burke et al. · From the abstract

Names both Creatine and Whey Protein in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

How to read this page

A literature summary, not guidance.

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Creatine, Whey Protein, and several hundred other substances.

Log your routine, get reminders at the times you choose, and scan a label to add a product. The checker is a research and organisation tool, not a clinical decision aid.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.