From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
CautionEmerging evidence
What is happening. L-Citrulline may add to the blood-pressure-lowering effect of Felodipine.
Mechanism. Additive vasodilation, nitric oxide signaling, or smooth-muscle relaxation can lower blood pressure further.
Recommendation. Monitor blood pressure and dizziness, especially during dose changes; stop the supplement and seek advice if syncope, falls, or symptomatic hypotension occurs.
Stack Score
How it moves the number.
Effect on the composite score
If both Felodipine and L-Citrulline are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Natural Medicines antihypertensive supplement interaction reviews.Needs sourceNo link