NutriStack
Fluconazole and Magnesium Glycinate, a synergy.
Fluconazole can prolong the QT interval, especially at higher doses, in renal impairment, or with other QT-prolonging drugs. Low magnesium and low potassium are independent, well-established risk factors for torsades de pointes. Keeping magnesium in the normal range reduces this background arrhythmia risk while you are taking fluconazole.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Fluconazole and Magnesium Glycinate
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Fluconazole can prolong the QT interval, especially at higher doses, in renal impairment, or with other QT-prolonging drugs. Low magnesium and low potassium are independent, well-established risk factors for torsades de pointes. Keeping magnesium in the normal range reduces this background arrhythmia risk while you are taking fluconazole.
Mechanism. Hypomagnesemia destabilizes cardiac repolarization and prolongs the QT interval. Fluconazole independently blocks hERG potassium currents, lengthening QT. Maintaining normal magnesium reduces additive arrhythmic risk.
Recommendation. If your magnesium is low or you are on a diuretic, correct deficiency before starting fluconazole and maintain adequate intake during the course. Do not megadose; typical magnesium glycinate doses (200-350 mg elemental/day) are appropriate.
Sources (2)
- Pham CP, et al. Long QTc interval and torsade de pointes caused by fluconazole. Ann Pharmacother. 2006;40(7-8):1456-61. PMID 16849620
- Tisdale JE. Drug-induced QT interval prolongation and torsades de pointes: Role of the pharmacist in risk assessment, prevention and management. Can Pharm J (Ott). 2016;149(3):139-52. PMID 27212965
Stack Score
How this pair moves the number.
Effect on the composite score
If both Fluconazole and Magnesium Glycinate are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.