What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Alcohol + Fluconazole pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Alcohol and Fluconazole, a caution.

Q: Can I take Alcohol and Fluconazole together?

Possibly, but with caution. Alcohol and Fluconazole have a documented caution-tier interaction. Fluconazole is hepatotoxic in a dose- and duration-dependent fashion, and alcohol is one of the strongest modifiable risk factors for drug-induced liver injury. Drinking during fluconazole therapy meaningfully raises the chance of transaminase elevation, cholestasis, or symptomatic hepatitis, particularly with longer courses or repeated exposures.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Fluconazole is hepatotoxic in a dose- and duration-dependent fashion, and alcohol is one of the strongest modifiable risk factors for drug-induced liver injury. Drinking during fluconazole therapy meaningfully raises the chance of transaminase elevation, cholestasis, or symptomatic hepatitis, particularly with longer courses or repeated exposures.

2 primary source citations. Moderate evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Alcohol and Fluconazole
Pair type: Caution
Evidence (highest tier): Moderate
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Moderate evidence

Caution

What is happening. Fluconazole is hepatotoxic in a dose- and duration-dependent fashion, and alcohol is one of the strongest modifiable risk factors for drug-induced liver injury. Drinking during fluconazole therapy meaningfully raises the chance of transaminase elevation, cholestasis, or symptomatic hepatitis, particularly with longer courses or repeated exposures.

Mechanism. Both alcohol and fluconazole generate reactive metabolites that deplete glutathione and stress hepatocytes. Alcohol also induces CYP2E1, increasing oxidative liver injury risk.

Recommendation. Avoid alcohol while taking fluconazole and for several days after the course ends. If you must drink, keep it to one occasion and minimize quantity, and tell your prescriber so liver enzymes can be checked.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Alcohol and Fluconazole are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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