NutriStack
Furosemide and Magnesium Glycinate, a synergy.
Furosemide depletes magnesium through its action on the thick ascending limb, where the majority of magnesium reabsorption occurs. Loop diuretic-induced hypomagnesemia is common and can contribute to refractory hypokalemia, muscle cramps, and cardiac arrhythmias.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Furosemide and Magnesium Glycinate
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 4 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Furosemide depletes magnesium through its action on the thick ascending limb, where the majority of magnesium reabsorption occurs. Loop diuretic-induced hypomagnesemia is common and can contribute to refractory hypokalemia, muscle cramps, and cardiac arrhythmias.
Mechanism. Furosemide inhibits NKCC2 in the thick ascending limb, which is the primary site of renal magnesium reabsorption (driven by the lumen-positive transepithelial voltage). By disrupting this electrochemical gradient, furosemide dramatically reduces paracellular magnesium reabsorption.
Recommendation. Monitor magnesium levels during furosemide therapy. Supplement with magnesium (200-400mg/day) as needed. Correcting magnesium depletion is essential for effectively correcting potassium depletion.
Sources (4)
- Dai LJ et al. Magnesium transport in the renal distal convoluted tubule. Physiol Rev. 2001;81(1):51-84. PMID 11152754
- Mah J, Pitre T. Oral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-Analysis.. BMC Complementary Medicine and Therapies. 2021. PMID 33865376
- Veronese N, Dominguez LJ, Pizzol D et al.. Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials.. Nutrients. 2021. PMID 34836329
- Veronese N, Pizzol D, Smith L et al.. Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials.. Nutrients. 2022. PMID 35277037
Stack Score
How this pair moves the number.
Effect on the composite score
If both Furosemide and Magnesium Glycinate are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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