NutriStack
Alcohol and Furosemide, a caution.
Furosemide can cause volume depletion, electrolyte loss, and orthostatic symptoms. Alcohol can impair vasoconstriction during standing and can worsen dehydration risk, so the combination can cause dizziness, falls, fainting, or kidney stress. Risk is higher after dose increases, during hot weather, with vomiting or diarrhea, or in older adults.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Alcohol and Furosemide
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 3 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Furosemide can cause volume depletion, electrolyte loss, and orthostatic symptoms. Alcohol can impair vasoconstriction during standing and can worsen dehydration risk, so the combination can cause dizziness, falls, fainting, or kidney stress. Risk is higher after dose increases, during hot weather, with vomiting or diarrhea, or in older adults.
Mechanism. Furosemide promotes natriuresis and volume contraction. Alcohol potentiates orthostatic hypotension by impairing vasoconstrictor responses to orthostatic stress and can add to fluid losses.
Recommendation. Limit alcohol while using furosemide, especially around dose changes or when you are already dehydrated. Stand slowly, maintain appropriate fluid intake for your condition, and seek care if you faint, cannot keep fluids down, or develop severe weakness.
Sources (3)
- Narkiewicz K, Cooley RL, Somers VK. Alcohol potentiates orthostatic hypotension: implications for alcohol-related syncope. Circulation. 2000;101(4):398-402. PMID 10653831
- Palma JA, Kaufmann H. Management of Orthostatic Hypotension. Continuum (Minneap Minn). 2020;26(1):154-177. PMID 31996627
- Brater DC. Diuretic therapy. N Engl J Med. 1998;339(6):387-395. PMID 9691107
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alcohol and Furosemide are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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