NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Alcohol and Furosemide: what the published research says

PubMed indexes 8 records that name Alcohol and Furosemide together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Alcohol and Furosemide. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Alcohol and Furosemide.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Hospital preparations of ethanol-free furosemide oral solutions: Formulation and stability study.

Journal of advanced pharmaceutical technology & research · 2022 · PMID 35464657

“Despite this slight decrease, the characteristics remained within the prescribed specifications. Based on the stability profile of the ethanol-free solution containing sorbitol, it could be implemented in hospitals for the care of pediatric patients.”

Sombié et al. · From the abstract

Names both Alcohol and Furosemide in its title.

Alcohol-free Extemporaneous Formulations of Furosemide Are Chemically and Physically Stable in Ora-Blend Products for 30 Days.

International journal of pharmaceutical compounding · 2020 · PMID 32401745

Human subjects

“A simple extemporaneous compounding method was used to prepare alcohol-free furosemide suspensions that were stable for 30 days at 4oC and 25oC. These findings are important for patients who cannot tolerate, or wish to avoid, alcohol, including the pediatric population.”

Svirskis et al. · From the abstract

Names both Alcohol and Furosemide in its title.

Furosemide ethanol-free oral solutions for paediatric use: formulation, HPLC method and stability study.

European journal of hospital pharmacy : science and practice · 2018 · PMID 31157009

“Both formulations were stable when stored at room temperature for up to 9 months; formulation F1 was stable even at 40°C. MP used as an antimicrobial agent fully satisfied the recommended criteria for preservative efficacy in oral preparations according to the European Pharmacopoeia 9.0 (5.1.3).”

Zahálka et al. · Authors' conclusion

Names both Alcohol and Furosemide in its title.

Brain damage due to episodic alcohol exposure in vivo and in vitro: furosemide neuroprotection implicates edema-based mechanism.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 1998 · PMID 9472987

Animal study

“We suggest that the neurodegeneration is elicited in part by edema-dependent oxidative stress, but the regional selectivity of the damage may be best explained by physical (mechanical) compression of the limbic cortex against the adjacent tympanic bulla and subsequent neuronal cytoskeletal collapse. A scheme for these apparently nonexcitotoxic metabolic and mechanical pathways initiated by repeated alcohol exposure is proposed.”

Collins et al. · From the abstract

Names both Alcohol and Furosemide in its title.

Acute effects of ethanol and ethanol plus furosemide on pancreatic capillary blood flow in rats.

American journal of surgery · 1993 · PMID 7687095

Animal study

“The depressant effect of ethanol on PCBF may be the result of its direct action on pancreatic cells causing edema and capillary compression rather than on primary vascular control mechanisms that adjust blood flow. Furosemide counters this effect.”

Dib et al. · From the abstract

Names both Alcohol and Furosemide in its title.

Furosemide and spironolactone doses and hyponatremia in patients with heart failure.

BMC pharmacology & toxicology · 2020 · PMID 32746925

Observational StudyHuman subjects

“High doses of furosemide and spironolactone, or concomitant use of these diuretics, seem to be an important cause of hyponatremia in HF patients, particularly in combination with advanced age, diabetes and alcohol consumption. Diuretic dose reduction may help avoid hyponatremia and improve clinical status and prognosis in such patients.”

Velat et al. · Authors' conclusion

Names Alcohol and Furosemide together in an interaction, co-administration, or pharmacokinetic context.

Diuretics and their potential effect on breath-alcohol concentration--a case report

Archiv fur Kriminologie · 2015 · PMID 26427279

Comparative StudyRandomized Controlled Trial

“In terms of the reported case and provided that no compensatory fluid had been taken, a purely theoretical maximum shift of 0.007 mg/ may occur in the breath-alcohol concentration due to the smaller distribution volume even considering maximum urinary excretion values. On the other hand, already mild levels of dehydration may be associated with negative symptoms affecting driving ability.”

Schmitt et al. · From the abstract

Names Alcohol and Furosemide together in an interaction, co-administration, or pharmacokinetic context.

Fenofibrate and warfarin interaction.

Pharmacotherapy · 2001 · PMID 11444587

Case ReportsHuman subjects

“His drug therapy profile consisted of digoxin, fosinopril, and furosemide for chronic heart failure, allopurinol for gout, and potassium supplementation. To minimize the risk of supratherapeutic INR values and/or hemorrhagic events, clinicians should perform serial monitoring of INR when initiating fenofibrate therapy in a patient previously stabilized on a coumarin anticoagulant.”

Aldridge et al. · From the abstract

Names Alcohol and Furosemide together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Alcohol, Furosemide, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.