NutriStack
Furosemide and Magnesium Taurate, a synergy.
Furosemide can cause clinically relevant magnesium depletion by increasing urinary magnesium excretion. Magnesium taurate may help replace magnesium, but the dose should be guided by symptoms, kidney function, and lab monitoring. People also taking digoxin or with arrhythmia history need extra attention because magnesium and potassium depletion can increase rhythm risk.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
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Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Furosemide and Magnesium Taurate
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 3 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Furosemide can cause clinically relevant magnesium depletion by increasing urinary magnesium excretion. Magnesium taurate may help replace magnesium, but the dose should be guided by symptoms, kidney function, and lab monitoring. People also taking digoxin or with arrhythmia history need extra attention because magnesium and potassium depletion can increase rhythm risk.
Mechanism. Furosemide blocks NKCC2 and lowers the transepithelial voltage that supports magnesium reabsorption in the thick ascending limb. Magnesium taurate provides supplemental magnesium to counter ongoing renal losses.
Recommendation. Do not assume cramps or palpitations are harmless while taking furosemide; ask about checking magnesium and potassium. If magnesium taurate is used, keep the dose consistent and review it with your prescriber if you have kidney disease or heart rhythm problems.
Sources (3)
- Brater DC. Diuretic therapy. N Engl J Med. 1998;339(6):387-395. PMID 9691107
- Mohn ES, Kern HJ, Saltzman E, Mitmesser SH, McKay DL. Evidence of Drug-Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update. Pharmaceutics. 2018;10(1):36. PMID 29558445
- Dai LJ, Ritchie G, Kerstan D, Kang HS, Cole DE, Quamme GA. Magnesium transport in the renal distal convoluted tubule. Physiol Rev. 2001;81(1):51-84. PMID 11152754
Stack Score
How this pair moves the number.
Effect on the composite score
If both Furosemide and Magnesium Taurate are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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