From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionInsufficient evidence
What is happening. Acidic vitamin C products layered with copper peptide cosmetics may increase irritation.
Mechanism. Topical formulation compatibility and skin barrier irritation.
Recommendation. Separate topical vitamin C and GHK-Cu if irritation occurs.
Stack Score
How it moves the number.
Effect on the composite score
If both GHK-Cu (Copper Peptide) and Vitamin C are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Li H et al. Microneedle-mediated delivery of copper peptide. Pharm Res. 2015.Needs sourceNo link