Supplement × Supplement·a caution·Insufficient evidence

GHK-Cu (Copper Peptide) + Vitamin C

Caution Insufficient evidence

Acidic vitamin C products layered with copper peptide cosmetics may increase irritation.

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Pair type
Caution
Evidence
Insufficient
Source citations
1
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionInsufficient evidence

What is happening. Acidic vitamin C products layered with copper peptide cosmetics may increase irritation.

Mechanism. Topical formulation compatibility and skin barrier irritation.

Recommendation. Separate topical vitamin C and GHK-Cu if irritation occurs.

Stack Score

How it moves the number.

Effect on the composite score

If both GHK-Cu (Copper Peptide) and Vitamin C are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1Li H et al. Microneedle-mediated delivery of copper peptide. Pharm Res. 2015.Needs sourceNo link

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