NutriStack
Glipizide and Vanadium, a caution.
Vanadium has insulin-like and insulin-sensitizing activity in PubMed-indexed human diabetes studies. Glipizide stimulates insulin release and can cause hypoglycemia, so adding vanadium may increase the chance of low blood sugar, particularly in older adults, kidney disease, missed meals, or dose escalation.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 3 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Vanadium has insulin-like and insulin-sensitizing activity in PubMed-indexed human diabetes studies. Glipizide stimulates insulin release and can cause hypoglycemia, so adding vanadium may increase the chance of low blood sugar, particularly in older adults, kidney disease, missed meals, or dose escalation.
Mechanism. Vanadium can improve insulin signaling and glucose handling. Glipizide increases pancreatic insulin secretion through sulfonylurea receptor activity, creating additive pharmacodynamic glucose-lowering potential.
Recommendation. Avoid starting vanadium while taking glipizide unless your diabetes clinician approves and monitoring is planned. Check glucose more often during any vanadium change and report recurrent lows, sweating, tremor, confusion, or nighttime symptoms. Do not self-adjust glipizide dose without clinician guidance.
Sources (3)
- Cusi K, Cukier S, DeFronzo RA, Torres M, Puchulu FM, Redondo JC. Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes. J Clin Endocrinol Metab. 2001;86(3):1410-1417. PMID 11238540
- Boden G, Chen X, Ruiz J, van Rossum GD, Turco S. Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. Metabolism. 1996;45(9):1130-1135. PMID 8781301
- Schopman JE, Simon AC, Hoefnagel SJ, Hoekstra JB, Scholten RJ, Holleman F. The incidence of mild and severe hypoglycaemia in patients with type 2 diabetes mellitus treated with sulfonylureas: a systematic review and meta-analysis. Diabetes Metab Res Rev. 2014;30(1):11-22. PMID 24030920
Stack Score
How this pair moves the number.
Effect on the composite score
If both Glipizide and Vanadium are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.