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Glycine and Magnesium Glycinate, a synergy.
Magnesium glycinate already contains glycine as its chelation partner. Additional glycine further supports sleep and inhibitory neurotransmission.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Glycine and Magnesium Glycinate
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Magnesium glycinate already contains glycine as its chelation partner. Additional glycine further supports sleep and inhibitory neurotransmission.
Mechanism. Glycine acts on NMDA receptors in the suprachiasmatic nucleus, lowering core body temperature to promote sleep onset. Combined with magnesium's NMDA antagonism, enhanced sleep quality.
Recommendation. Magnesium glycinate provides both magnesium and glycine. Supplemental glycine (3g) can further enhance sleep quality.
Sources (1)
- Bannai M, Kawai N. New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep. J Pharmacol Sci. 2012
Stack Score
How this pair moves the number.
Effect on the composite score
If both Glycine and Magnesium Glycinate are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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