NutriStack
Hyaluronic Acid and MSM, a synergy.
MSM supplies bioavailable sulfur that supports glycosaminoglycan and connective tissue synthesis, complementing hyaluronic acid for joint comfort and skin hydration.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Hyaluronic Acid and MSM
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. MSM supplies bioavailable sulfur that supports glycosaminoglycan and connective tissue synthesis, complementing hyaluronic acid for joint comfort and skin hydration.
Mechanism. Hyaluronic acid is a major glycosaminoglycan of synovial fluid and skin, while MSM donates sulfur used in synthesis of sulfated glycosaminoglycans and collagen cross-linking and exerts anti-inflammatory effects, so the two support extracellular matrix integrity through complementary routes.
Recommendation. Reasonable to combine in joint or skin protocols (for example oral hyaluronic acid 80 to 200mg with MSM 1 to 3g daily). No timing restriction needed.
Sources (2)
- Butawan M, Benjamin RL, Bloomer RJ. Methylsulfonylmethane: applications and safety of a novel dietary supplement. Nutrients. 2017
- Oe M, et al. Oral hyaluronan relieves knee pain: a review. Nutrition Journal. 2016
Stack Score
How this pair moves the number.
Effect on the composite score
If both Hyaluronic Acid and MSM are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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