NutriStack
Hyaluronic Acid and Vitamin C, a synergy.
Vitamin C is a required cofactor for collagen synthesis, supporting the extracellular matrix environment where hyaluronic acid contributes hydration.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Hyaluronic Acid and Vitamin C
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Vitamin C is a required cofactor for collagen synthesis, supporting the extracellular matrix environment where hyaluronic acid contributes hydration.
Mechanism. Vitamin C acts as a cofactor for prolyl and lysyl hydroxylase in collagen synthesis and supports fibroblast function, complementing hyaluronic acid's role in matrix hydration.
Recommendation. Reasonable to combine for skin and connective tissue support. No timing constraint required.
Sources (2)
- Pullar JM, Carr AC, Vissers MCM, The roles of vitamin C in skin health, Nutrients, 2017
- Oe M et al., Oral hyaluronan relieves knee pain: a review, Nutrition Journal, 2016
Stack Score
How this pair moves the number.
Effect on the composite score
If both Hyaluronic Acid and Vitamin C are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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