NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Polyethylene Glycol and Vitamin C: what the published research says

PubMed indexes 8 records that name Polyethylene Glycol and Vitamin C together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Polyethylene Glycol and Vitamin C. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Polyethylene Glycol and Vitamin C.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Comparative Efficacy of 2 L Polyethylene Glycol Alone or With Ascorbic Acid vs. 4 L Polyethylene Glycol for Colonoscopy: A Systematic Review and Network Meta-Analysis of 12 Randomized Controlled Trials.

Frontiers in medicine · 2019 · PMID 31497604

Systematic Review

“Conclusions: As for bowel preparation before colonoscopy, 2 L PEG ascorbic acid with split dose should be optimally prescribed. Further studies investigating the comparative efficacy of 2 L PEG related to 4 L PEG, 4 L PEG with split dose, and 2 L PEG plus ascorbic acid with split dose, respectively are needed.”

Tian et al. · From the abstract

Names both Polyethylene Glycol and Vitamin C in its title.

A meta-analysis of randomized controlled trials of low-volume polyethylene glycol plus ascorbic acid versus standard-volume polyethylene glycol solution as bowel preparations for colonoscopy.

PloS one · 2014 · PMID 24902028

Meta-AnalysisHuman subjects

“Low-volume PEG plus ascorbic acid gut lavage achieved non-inferior efficacy for bowel cleansing, is more acceptable to patients, and has fewer side effects than standard-volume PEG as a bowel preparation method for colonoscopy.”

Xie et al. · Authors' conclusion

Names both Polyethylene Glycol and Vitamin C in its title.

Comparative Efficacy and Safety of 0.8-L Versus 2-L Polyethylene Glycol-Ascorbic Acid Solutions in Colonoscopy Preparation: A Prospective, Multicenter, Randomized, Controlled Trial.

Journal of gastroenterology and hepatology · 2025 · PMID 40704430

Multicenter StudyRandomized Controlled TrialComparative Study

“The novel 0.8-L PEG-ascorbic acid solution was effective, safe, and highly tolerable, showing noninferiority to the 2-L PEG-ascorbic acid solution. The same-day regimen showed a tendency toward better cleansing efficacy in the ascending colon and higher patient satisfaction.”

Lee et al. · Authors' conclusion

Names both Polyethylene Glycol and Vitamin C in its title.

Retrospective Analysis of Bowel Bubbles During Colonoscopy Following Bowel Preparation with Oral Sulfate Solution or 2 L Polyethylene Glycol-Electrolyte Solution with Ascorbic Acid.

Digestive diseases and sciences · 2025 · PMID 40745241

Multicenter StudyHuman subjects162 participants

“The rates of bubbles in each segment were examined by BBS-C, and good bowel preparation was a risk factor for proximal severe bubbles. There was no significant difference regarding severe bubbles between OSS and PEG.”

Ahmad et al. · Authors' conclusion

Names both Polyethylene Glycol and Vitamin C in its title.

1-L polyethylene glycol + ascorbic acid versus sodium picosulfate + magnesium citrate bowel preparations for colonoscopy: effectiveness and safety.

Revista espanola de enfermedades digestivas · 2024 · PMID 37982567

Randomized Controlled Trial

“in our real-life setting, 1-L PEG + ASC offered better adequate and HQ bowel cleansing than SPMC, achieving excellent cleansing quality, regardless of gender or tolerance.”

PĂ©rez Arellano et al. · Authors' conclusion

Names both Polyethylene Glycol and Vitamin C in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Polyethylene Glycol, Vitamin C, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.