What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 5 citation rows for the Iron + Lisinopril pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Iron and Lisinopril, timing-sensitive.

Q: Can I take Iron and Lisinopril together?

Yes, if you separate them in time. Iron and Lisinopril have a documented timing-sensitive interaction. Iron supplements may modestly reduce the absorption of ACE inhibitors when taken simultaneously. While the interaction is minor compared to other iron-drug chelations, separating doses is a reasonable precaution to ensure optimal drug absorption.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Iron supplements may modestly reduce the absorption of ACE inhibitors when taken simultaneously. While the interaction is minor compared to other iron-drug chelations, separating doses is a reasonable precaution to ensure optimal drug absorption.

5 primary source citations. Emerging evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Iron and Lisinopril
Pair type: Timing Sensitive
Evidence (highest tier): Emerging
Source citations: 5 sources
Stack Score effect: −5 to your Stack Score (per scored timing-sensitive row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Timing Sensitive · Emerging evidence

Timing Sensitive

What is happening. Iron supplements may modestly reduce the absorption of ACE inhibitors when taken simultaneously. While the interaction is minor compared to other iron-drug chelations, separating doses is a reasonable precaution to ensure optimal drug absorption.

Mechanism. Iron may form weak chelation complexes with the carboxyl groups of ACE inhibitors, modestly reducing their dissolution and absorption in the GI tract. The interaction is considerably less significant than iron chelation with tetracyclines or fluoroquinolones.

Recommendation. Separate lisinopril and iron supplements by at least 2 hours as a precaution. This is a minor interaction and unlikely to be clinically significant at standard doses, but good practice for maximizing drug absorption.

Minimum separation. 120

Sources (5)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Iron and Lisinopril are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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