What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Lisinopril + Magnesium Citrate pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Lisinopril and Magnesium Citrate, a synergy.

Q: Can I take Lisinopril and Magnesium Citrate together?

Yes. The combination of Lisinopril and Magnesium Citrate produces a measurable benefit. Magnesium supplementation lowers blood pressure modestly, with meta-analyses reporting about 2-3 mm Hg systolic and 2 mm Hg diastolic reductions in hypertensive patients on antihypertensive medication. Combined with lisinopril, the effect is additive and generally beneficial, though it may produce mild hypotension if blood pressure is already at goal. The risk of meaningful hyperkalemia from magnesium itself is low.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Magnesium supplementation lowers blood pressure modestly, with meta-analyses reporting about 2-3 mm Hg systolic and 2 mm Hg diastolic reductions in hypertensive patients on antihypertensive medication. Combined with lisinopril, the effect is additive and generally beneficial, though it may produce mild hypotension if blood pressure is already at goal. The risk of meaningful hyperkalemia from magnesium itself is low.

2 primary source citations. Strong evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Lisinopril and Magnesium Citrate
Pair type: Synergy
Evidence (highest tier): Strong
Source citations: 2 sources
Stack Score effect: +2 to your Stack Score (per scored synergy row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Synergy · Strong evidence

Synergy

What is happening. Magnesium supplementation lowers blood pressure modestly, with meta-analyses reporting about 2-3 mm Hg systolic and 2 mm Hg diastolic reductions in hypertensive patients on antihypertensive medication. Combined with lisinopril, the effect is additive and generally beneficial, though it may produce mild hypotension if blood pressure is already at goal. The risk of meaningful hyperkalemia from magnesium itself is low.

Mechanism. Magnesium acts as a calcium channel modulator in vascular smooth muscle, promotes nitric oxide release, and inhibits angiotensin-induced vasoconstriction. These actions complement ACE inhibition.

Recommendation. Magnesium Citrate 200-350 mg elemental magnesium daily is a reasonable add-on; monitor home blood pressure after starting. Tell your prescriber so your lisinopril dose can be reviewed. Reduce dose if you develop loose stools.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Lisinopril and Magnesium Citrate are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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