NutriStack
Lisinopril and Quercetin, a synergy.
Quercetin lowers blood pressure modestly (about 5-7 mm Hg systolic in stage 1 hypertensives) through endothelial improvement, AT1 receptor downregulation, and natriuresis. Combined with lisinopril the effects are additive and generally well tolerated, though mild hypotension is possible if blood pressure is already at goal.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Lisinopril and Quercetin
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Quercetin lowers blood pressure modestly (about 5-7 mm Hg systolic in stage 1 hypertensives) through endothelial improvement, AT1 receptor downregulation, and natriuresis. Combined with lisinopril the effects are additive and generally well tolerated, though mild hypotension is possible if blood pressure is already at goal.
Mechanism. Quercetin downregulates renal angiotensin I receptors, increases urinary sodium excretion, and improves endothelial function. These actions complement ACE inhibition by lisinopril.
Recommendation. Quercetin 500 mg twice daily is a typical research dose; monitor home blood pressure after starting and tell your prescriber so your lisinopril dose can be reviewed. Take with food to limit GI upset.
Sources (2)
- Edwards RL, Lyon T, Litwin SE, Rabovsky A, Symons JD, Jalili T. Quercetin reduces blood pressure in hypertensive subjects. J Nutr. 2007;137(11):2405-11. PMID 17951477
- Larson AJ, Symons JD, Jalili T. Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms. Adv Nutr. 2012;3(1):39-46. PMID 22332099
Stack Score
How this pair moves the number.
Effect on the composite score
If both Lisinopril and Quercetin are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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