NutriStack
Magnesium Citrate and Manganese, timing-sensitive.
Taking a large magnesium dose at the same time as manganese may slightly reduce manganese absorption through general divalent-mineral interference in the gut. The effect is small and mostly relevant only when manganese intake is already marginal or when high magnesium doses (a common scenario, since magnesium is often dosed at 200 to 400 mg) are co-ingested with a manganese supplement.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- Magnesium Citrate and Manganese
- Pair type
- Timing Sensitive
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored timing-sensitive row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Timing Sensitive · Emerging evidence
Timing Sensitive
What is happening. Taking a large magnesium dose at the same time as manganese may slightly reduce manganese absorption through general divalent-mineral interference in the gut. The effect is small and mostly relevant only when manganese intake is already marginal or when high magnesium doses (a common scenario, since magnesium is often dosed at 200 to 400 mg) are co-ingested with a manganese supplement.
Mechanism. Manganese and magnesium are both divalent cations (Mn2+ and Mg2+). At high luminal concentrations, divalent minerals can interfere with one another's intestinal handling, so a large single magnesium dose taken alongside manganese may modestly reduce manganese uptake. Note that the two minerals use largely different primary pathways (manganese relies substantially on DMT1, while magnesium is absorbed mainly via TRPM6/TRPM7 channels and paracellular routes), so any competition is partial and the human evidence is limited.
Recommendation. This pairing is fine for most people, but if you are specifically correcting a manganese shortfall, separate the two by about 2 hours. Take manganese (typically 1 to 2 mg, and rarely above the 11 mg adult upper limit) away from your largest magnesium dose. If you take magnesium at night for sleep, take manganese with a different meal during the day.
Minimum separation. 2 hours
Sources (2)
- General trace-mineral and divalent cation absorption reviews describing competitive interference among co-ingested minerals at high doses.
- Reviews of intestinal mineral transport noting distinct primary pathways for manganese (DMT1) versus magnesium (TRPM6/TRPM7 and paracellular).
Stack Score
How this pair moves the number.
Effect on the composite score
If both Magnesium Citrate and Manganese are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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