NSTK · 01.2026Independent supplement reference

Edition 1.0Updated August 1, 2026

Supplement × Supplement·Evidence index

Calcium and Manganese: what the published research says

PubMed indexes 5 records that name Calcium and Manganese together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Reviews & meta-analyses

Read the studies ↓ How we select sources

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Calcium and Manganese. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

A study appearing here is not proof that an interaction exists. Two substances can be named together in a paper that never tested them in combination, and a source listed as background may cover only one of them.
Findings are quoted from each abstract as the authors wrote them. NutriStack has not re-analysed, pooled, or reconciled them, and they may disagree with each other.
NutriStack’s own interaction assessment for this pair is not published here. It has not completed qualified-human clinical review, so it is withheld from search. See the publication gate.
Nothing here is medical advice. Decisions about prescription medication and supplements belong with your prescriber or pharmacist, who can see your full regimen.

The research

5 studies naming Calcium and Manganese.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Insights into molecular and cellular functions of the Golgi calcium/manganese-proton antiporter TMEM165.

The Journal of biological chemistry · 2024 · PMID 39002685

Research Support, N.I.H., ExtramuralSystematic ReviewHuman subjects

Names both Calcium and Manganese in its title.

Exploring Calcium Manganese Oxide as a Promising Cathode Material for Calcium-Ion Batteries.

Chemistry of materials : a publication of the American Chemical Society · 2023 · PMID 37901147

“CaMn2O4 can cycle at a capacity of 52 mAh/g at a rate of C/33, and calcium cycling is verified with energy-dispersive X-ray spectroscopy (EDS) and X-ray photoelectron spectroscopy (XPS) and modeled with density functional theory (DFT) simulations. The results from the investigation concluded that CaMn2O4 is a promising cathode for calcium-ion batteries.”
Chando et al. · From the abstract

Names both Calcium and Manganese in its title.

Transport, functions, and interaction of calcium and manganese in plant organellar compartments.

Plant physiology · 2021 · PMID 35235665

Review

Names both Calcium and Manganese in its title.

Role for calcium signaling in manganese neurotoxicity.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2019 · PMID 31470248

ReviewHuman subjects

“Ca2+ regulation influences the neurodegenerative process and there is possible role for perturbed calcium signaling in Mn neurotoxicity. Mechanisms implicated in Mn-induced neurodegeneration include oxidative stress, generation of free radicals, and apoptosis. These are influenced by mitochondrial integrity which can be dependent on intracellular Ca2+ homeostasis.”
Ijomone et al. · Authors' conclusion

Names both Calcium and Manganese in its title.

Manganese and calcium transport in mitochondria: implications for manganese toxicity.

Neurotoxicology · 1999 · PMID 10385903

ReviewHuman subjects

Names both Calcium and Manganese in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

Selection. These records were found by searching PubMed titles and abstracts for both substance names alongside interaction and pharmacokinetic terms. Relevant work that phrases things differently, or is not indexed in PubMed, will be missing.
No effect size. The quoted conclusions are the authors’ words about their own study. We have not extracted effect direction or magnitude, and a single study’s conclusion is not a consensus.
Population mismatch. Findings in healthy volunteers, animals, or a specific patient group may not transfer to you, your dose, or your formulation.
Absence is not safety. Few published studies means the combination is under-studied, which is not the same as established as safe.

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Calcium, Manganese, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

Get NutriStack free → Read the methodology

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.