NutriStack
Iron and Manganese, timing-sensitive.
Iron and manganese compete for shared intestinal absorption pathways, so high-dose iron can reduce manganese uptake, and conversely high manganese intake can blunt iron absorption.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Timing Sensitive
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored timing-sensitive row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Timing Sensitive · Moderate evidence
Timing Sensitive
What is happening. Iron and manganese compete for shared intestinal absorption pathways, so high-dose iron can reduce manganese uptake, and conversely high manganese intake can blunt iron absorption.
Mechanism. Both divalent metals are absorbed in part via the divalent metal transporter 1 (DMT1) in the gut, so high intake of one cation competitively reduces absorption of the other.
Recommendation. Separate iron and manganese doses by at least 2 hours to limit absorption competition, and take iron with vitamin C to improve its uptake.
Minimum separation. 2 hours
Stack Score
How this pair moves the number.
Effect on the composite score
If both Iron and Manganese are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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