NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Supplement·Evidence index

Magnesium Citrate and Potassium: what the published research says

PubMed indexes 8 records that name Magnesium Citrate and Potassium together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Magnesium Citrate and Potassium. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Magnesium Citrate and Potassium.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Potassium Magnesium Citrate Is Superior to Potassium Chloride in Reversing Metabolic Side Effects of Chlorthalidone.

Hypertension (Dallas, Tex. : 1979) · 2023 · PMID 37846572

Randomized Controlled Trial

“KMgCit is superior to KCl, the common form of K supplement used in clinical practice, in preventing TD-induced hyperglycemia. This action may improve tolerability and cardiovascular safety in patients with hypertension treated with this drug class.”

Vongpatanasin et al. · Authors' conclusion

Names both Magnesium Citrate and Potassium in its title.

Reduction of renal stone risk by potassium-magnesium citrate during 5 weeks of bed rest.

The Journal of urology · 2007 · PMID 17509313

Randomized Controlled TrialResearch Support, N.I.H., Extramural

“Provision of alkali as potassium-magnesium citrate is an effective countermeasure for the increased risk of renal stone disease associated with immobilization. Despite an increase in urine calcium concentration, the relative saturation of calcium oxalate decreased due to citrate chelation of calcium and the concentration of undissociated uric acid decreased due to the significant increase in urine pH.”

Zerwekh et al. · Authors' conclusion

Names both Magnesium Citrate and Potassium in its title.

Prevention of thiazide-induced hypokalemia without magnesium depletion by potassium-magnesium-citrate.

American journal of therapeutics · 2006 · PMID 16645424

Randomized Controlled TrialResearch Support, N.I.H., Extramural

“Though not conclusive, KCl supplementation may be less effective than K-Mg-citrate in maintaining normokalemia because of a subtle magnesium wasting. Moreover, KCl is devoid of protective action toward crystallization of stone-forming salts.”

Odvina et al. · From the abstract

Names both Magnesium Citrate and Potassium in its title.

Potassium-magnesium citrate versus potassium chloride in thiazide-induced hypokalemia.

Kidney international · 2000 · PMID 10652038

Clinical TrialComparative StudyRandomized Controlled Trial

“KMgCit is equally effective as potassium chloride in correcting thiazide-induced hypokalemia. In addition, KMgCit, but not potassium chloride, produces a small but significant increase in serum magnesium concentration by delivering a magnesium load, and it confers alkalinizing and citraturic actions.”

Wuermser et al. · Authors' conclusion

Names both Magnesium Citrate and Potassium in its title.

Effect of potassium magnesium citrate on thiazide-induced hypokalemia and magnesium loss.

American journal of kidney diseases : the official journal of the National Kidney Foundation · 1999 · PMID 10401023

Clinical TrialRandomized Controlled Trial

“Potassium magnesium citrate and potassium citrate, but not magnesium citrate, significantly increased urinary pH and citrate values. Potassium magnesium citrate not only corrects thiazide-induced hypokalemia, but also may avert magnesium loss while providing an alkali load.”

Ruml et al. · From the abstract

Names both Magnesium Citrate and Potassium in its title.

Effect of varying doses of potassium-magnesium citrate on thiazide-induced hypokalemia and magnesium loss.

American journal of therapeutics · 1999 · PMID 10423646

Clinical TrialRandomized Controlled Trial

“Potassium-magnesium citrate at a dosage of 4 tablets per day is adequate to correct thiazide-induced hypokalemia and to increase urinary pH and citrate sufficiently for stone prevention. Higher dosages are probably required for the prevention of magnesium loss and adverse symptoms of thiazide therapy.”

Ruml et al. · From the abstract

Names both Magnesium Citrate and Potassium in its title.

Effect of potassium-magnesium citrate on upper gastrointestinal mucosa.

Alimentary pharmacology & therapeutics · 1998 · PMID 9692708

Clinical TrialComparative StudyRandomized Controlled Trial

“Short-term use of K-Mag does not appear to induce lesions in the upper gastrointestinal mucosa and its oral tolerance is similar to Urocit-K or placebo.”

Gonzalez et al. · Authors' conclusion

Names both Magnesium Citrate and Potassium in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Magnesium Citrate, Potassium, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.