Interaction databaseSupplement × SupplementReviewed May 2026

Magnesium Citrate and Potassium, a synergy.

Magnesium deficiency causes renal potassium wasting. Correcting magnesium is often necessary before potassium levels can normalize.

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

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From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances
Magnesium Citrate and Potassium
Pair type
Synergy
Evidence (highest tier)
Strong
Source citations
1 source
Stack Score effect
+2 to your Stack Score (per scored synergy row).
Scope
Supplement × Supplement
Last verified
May 30, 2026

Synergy · Strong evidence

Synergy

What is happening. Magnesium deficiency causes renal potassium wasting. Correcting magnesium is often necessary before potassium levels can normalize.

Mechanism. Magnesium maintains ROMK channel function in the renal collecting duct. Mg deficiency causes ROMK-mediated potassium secretion, leading to renal potassium wasting resistant to K supplementation alone.

Recommendation. If hypokalemic, check magnesium status. Refractory hypokalemia often resolves only when magnesium is also repleted.

Sources (1)
  1. Huang CL et al. Mechanism of hypokalemia in magnesium deficiency. J Am Soc Nephrol. 2007;18(10):2649-52. PMID 17804670

Stack Score

How this pair moves the number.

Effect on the composite score

If both Magnesium Citrate and Potassium are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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