Magnesium Citrate and Potassium, a synergy.
Magnesium deficiency causes renal potassium wasting. Correcting magnesium is often necessary before potassium levels can normalize.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Magnesium Citrate and Potassium
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Magnesium deficiency causes renal potassium wasting. Correcting magnesium is often necessary before potassium levels can normalize.
Mechanism. Magnesium maintains ROMK channel function in the renal collecting duct. Mg deficiency causes ROMK-mediated potassium secretion, leading to renal potassium wasting resistant to K supplementation alone.
Recommendation. If hypokalemic, check magnesium status. Refractory hypokalemia often resolves only when magnesium is also repleted.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Magnesium Citrate and Potassium are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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