NutriStack
Magnesium Glycinate and Risedronate, timing-sensitive.
Magnesium is a divalent cation that chelates risedronate in the gut lumen and prevents it from being absorbed. Studies of mineral water rich in magnesium and calcium have shown markedly reduced risedronate uptake when the two are taken together.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Magnesium Glycinate and Risedronate
- Pair type
- Timing Sensitive
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored timing-sensitive row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Timing Sensitive · Strong evidence
Timing Sensitive
What is happening. Magnesium is a divalent cation that chelates risedronate in the gut lumen and prevents it from being absorbed. Studies of mineral water rich in magnesium and calcium have shown markedly reduced risedronate uptake when the two are taken together.
Mechanism. Mg2+ binds to the phosphonate moieties of risedronate, forming an insoluble complex that cannot cross the enterocyte and reach systemic circulation.
Recommendation. Take risedronate with plain water on an empty stomach, then wait at least 60 minutes before taking magnesium. Dosing magnesium at night and risedronate in the morning is the simplest fix.
Minimum separation. 60
Sources (2)
- Itoh A, Akagi Y, Shimomura H, Aoyama T. Interaction between Bisphosphonates and Mineral Water: Study of Oral Risedronate Absorption in Rats. Biol Pharm Bull. 2016;39(3):323-8. PMID 26934925
- Wiesner A, Szuta M, Galanty A, Paśko P. Optimal Dosing Regimen of Osteoporosis Drugs in Relation to Food Intake as the Key for the Enhancement of the Treatment Effectiveness-A Concise Literature Review. Foods. 2021;10(4):720. PMID 33805435
Stack Score
How this pair moves the number.
Effect on the composite score
If both Magnesium Glycinate and Risedronate are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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