NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Calcium and Risedronate: what the published research says

PubMed indexes 4 records that name Calcium and Risedronate together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Calcium and Risedronate. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

4 studies naming Calcium and Risedronate.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women.

The Cochrane database of systematic reviews · 2022 · PMID 35502787

Systematic ReviewHuman subjects

“This update recaps the key findings from our previous review that, for secondary prevention, risedronate 5 mg/day probably prevents non-vertebral fracture, and may reduce the risk of hip fractures. We are uncertain on whether risedronate 5mg/day reduces clinical vertebral and wrist fractures. Compared to placebo, risedronate probably does not increase the risk of serious adverse events.”

Wells et al. · Authors' conclusion

Names Calcium and Risedronate together in an interaction, co-administration, or pharmacokinetic context.

Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women.

The Cochrane database of systematic reviews · 2008 · PMID 18254053

Meta-AnalysisSystematic ReviewHuman subjects

“At 5 mg/day a statistically significant and clinically important benefit in the secondary prevention of vertebral, non-vertebral and hip fractures was observed, but not for wrist. The level of evidence for secondary prevention is Gold (www.cochranemsk.org) for vertebral and non-vertebral and Silver for hip and wrist. There were no statistically significant reductions in the primary prevention of vertebral and non-vertebral fractures. The level of evidence is Silver.”

Wells et al. · Authors' conclusion

Names Calcium and Risedronate together in an interaction, co-administration, or pharmacokinetic context.

Serum 25-hydroxy-vitamin D and the risk of fractures in the teriparatide versus risedronate VERO clinical trial.

Archives of osteoporosis · 2019 · PMID 30659410

Randomized Controlled Trial

“Serum 25(OH)D concentration decreases during teriparatide treatment. Fracture risk reduction with teriparatide versus risedronate did not significantly differ between the two groups of patients defined by baseline 25(OH)D.”

Minisola et al. · Authors' conclusion

Names Calcium and Risedronate together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Calcium, Risedronate, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.