NutriStack
Risedronate and Zinc, timing-sensitive.
Zinc, like calcium, iron, and magnesium, is a divalent cation that can complex with risedronate in the gut and reduce its absorption. Risedronate's oral bioavailability is already only about 1%, so any further chelation matters.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Risedronate and Zinc
- Pair type
- Timing Sensitive
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored timing-sensitive row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Timing Sensitive · Moderate evidence
Timing Sensitive
What is happening. Zinc, like calcium, iron, and magnesium, is a divalent cation that can complex with risedronate in the gut and reduce its absorption. Risedronate's oral bioavailability is already only about 1%, so any further chelation matters.
Mechanism. Zn2+ binds the phosphonate groups of risedronate to form a poorly soluble complex, decreasing the drug fraction available for intestinal absorption.
Recommendation. Take risedronate with plain water on an empty stomach and wait at least 60 minutes before any zinc-containing supplement or multivitamin. Bedtime zinc dosing pairs well with morning risedronate.
Minimum separation. 60
Sources (2)
- Kim JS, Jang SW, Son M, Kim BM, Kang MJ. Enteric-coated tablet of risedronate sodium in combination with phytic acid, a natural chelating agent, for improved oral bioavailability. Eur J Pharm Sci. 2016;82:36-42. PMID 26594027
- Wiesner A, Szuta M, Galanty A, Paśko P. Optimal Dosing Regimen of Osteoporosis Drugs in Relation to Food Intake as the Key for the Enhancement of the Treatment Effectiveness-A Concise Literature Review. Foods. 2021;10(4):720. PMID 33805435
Stack Score
How this pair moves the number.
Effect on the composite score
If both Risedronate and Zinc are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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