NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

MDMA and Pseudoephedrine: what the published research says

PubMed indexes 4 records that name MDMA and Pseudoephedrine together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to MDMA and Pseudoephedrine. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

4 studies naming MDMA and Pseudoephedrine.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Adsorption and desorption characteristics of methamphetamine, 3,4-methylenedioxymethamphetamine, and pseudoephedrine in soils.

Environmental science and pollution research international · 2015 · PMID 24838127

“However, pseudoephedrine recorded lower organic carbon normalized adsorption coefficient values (<250 mL g(-1)), lower magnitudes of Gibb's free energy change, and higher percent desorption (73-92 %) compared to methamphetamine and MDMA. The results thus showed pseudoephedrine to be the most mobile compound in the soils under study, to have the highest availability for degradation of the three compounds, and to have the highest susceptibility to biotic degradation in test…”

Pal et al. · From the abstract

Names both MDMA and Pseudoephedrine in its title.

Central serous chorioretinopathy associated with administration of sympathomimetic agents.

American journal of ophthalmology · 2003 · PMID 12834690

Case ReportsHuman subjects

“Patients afflicted with central serous chorioretinopathy should be notified about its possible association with sympathomimetic medications.”

Michael et al. · Authors' conclusion

Names MDMA and Pseudoephedrine together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers MDMA, Pseudoephedrine, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.