NutriStack
Medroxyprogesterone and Vitamin B6, a synergy.
DMPA can cause or worsen low mood in some users, and depleted B6 status (common in women on hormonal contraception) may contribute. Modest B6 supplementation supports neurotransmitter synthesis and may improve tolerability.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
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What the row says.
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At a glance
- Substances
- Medroxyprogesterone and Vitamin B6
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. DMPA can cause or worsen low mood in some users, and depleted B6 status (common in women on hormonal contraception) may contribute. Modest B6 supplementation supports neurotransmitter synthesis and may improve tolerability.
Mechanism. B6 is a cofactor for synthesis of serotonin, dopamine, and GABA. Progestins can shift tryptophan metabolism and B6 utilization, and adequate B6 supports neurotransmitter balance.
Recommendation. Consider B6 25-50 mg/day (as pyridoxine or P5P) during DMPA use, especially if you experience low mood or irritability. Take with or without food at any time of day.
Sources (2)
- Var C, Keller S, Tung R, Freeland D, Bazzano AN. Supplementation with vitamin B6 reduces side effects in Cambodian women using oral contraception. Nutrients. 2014;6(9):3353-62. PMID 25163030
- Palmery M, Saraceno A, Vaiarelli A, Carlomagno G. Oral contraceptives and changes in nutritional requirements. Eur Rev Med Pharmacol Sci. 2013;17(13):1804-13. PMID 23852908
Stack Score
How this pair moves the number.
Effect on the composite score
If both Medroxyprogesterone and Vitamin B6 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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