NutriStack
Medroxyprogesterone and Vitamin D3, a synergy.
Vitamin D adequacy is essential for the bone-protective effect of calcium during DMPA use. Without adequate vitamin D, dietary calcium cannot be efficiently absorbed and DMPA-related bone loss is more pronounced.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Medroxyprogesterone and Vitamin D3
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Vitamin D adequacy is essential for the bone-protective effect of calcium during DMPA use. Without adequate vitamin D, dietary calcium cannot be efficiently absorbed and DMPA-related bone loss is more pronounced.
Mechanism. Vitamin D upregulates intestinal calcium absorption via TRPV6 and calbindin and suppresses PTH-driven bone resorption. DMPA-induced estrogen suppression accelerates resorption, making adequate vitamin D more important.
Recommendation. Take vitamin D3 800-2000 IU/day while on DMPA, targeting serum 25(OH)D above 30 ng/mL. Take with a fatty meal at any time of day.
Sources (2)
- Guilbert ER, Brown JP, Kaunitz AM, et al. The use of depot-medroxyprogesterone acetate in contraception and its potential impact on skeletal health. Contraception. 2009;79(3):167-77. PMID 19185668
- Catalano A, Bellone F, Morabito N, et al. Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with Osteoporosis. Nutrients. 2021;13(6):1878. PMID 34072655
Stack Score
How this pair moves the number.
Effect on the composite score
If both Medroxyprogesterone and Vitamin D3 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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