NutriStack
Medroxyprogesterone and Vitamin K2, a synergy.
Vitamin K2 complements calcium and vitamin D for bone protection during DMPA use by activating osteocalcin and matrix Gla protein. Although direct DMPA-K2 trials are limited, the mechanism and extrapolation from postmenopausal osteoporosis data supports use.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Medroxyprogesterone and Vitamin K2
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Vitamin K2 complements calcium and vitamin D for bone protection during DMPA use by activating osteocalcin and matrix Gla protein. Although direct DMPA-K2 trials are limited, the mechanism and extrapolation from postmenopausal osteoporosis data supports use.
Mechanism. Vitamin K2 is the cofactor for gamma-glutamyl carboxylase, which activates osteocalcin (bone-mineralizing protein) and matrix Gla protein (vascular protector). It supports the calcium-vitamin D axis during DMPA-induced estrogen suppression.
Recommendation. Vitamin K2 (MK-7 90-180 mcg/day) is a reasonable addition to calcium and vitamin D for women on long-term DMPA. Take with a fatty meal. Avoid if you also take warfarin.
Sources (2)
- Iwamoto J. Vitamin K2 therapy for postmenopausal osteoporosis. Nutrients. 2014;6(5):1971-80. PMID 24841104
- Guilbert ER, Brown JP, Kaunitz AM, et al. The use of depot-medroxyprogesterone acetate in contraception and its potential impact on skeletal health. Contraception. 2009;79(3):167-77. PMID 19185668
Stack Score
How this pair moves the number.
Effect on the composite score
If both Medroxyprogesterone and Vitamin K2 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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