NutriStack
Magnesium Glycinate and Medroxyprogesterone, a synergy.
Magnesium plays a structural and signaling role in bone health and supports the calcium-vitamin D-PTH axis. Although direct DMPA trials are limited, magnesium adequacy is reasonable for women on long-term DMPA, especially given the BMD concern.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Magnesium Glycinate and Medroxyprogesterone
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Magnesium plays a structural and signaling role in bone health and supports the calcium-vitamin D-PTH axis. Although direct DMPA trials are limited, magnesium adequacy is reasonable for women on long-term DMPA, especially given the BMD concern.
Mechanism. Magnesium is required for vitamin D activation (1-alpha-hydroxylase) and PTH secretion regulation. Low magnesium impairs both calcium homeostasis and bone matrix mineralization.
Recommendation. Aim for daily magnesium needs from diet plus modest supplements during long-term DMPA use. Magnesium glycinate or citrate are well tolerated; take in the evening for sleep benefit.
Sources (2)
- Guilbert ER, Brown JP, Kaunitz AM, et al. The use of depot-medroxyprogesterone acetate in contraception and its potential impact on skeletal health. Contraception. 2009;79(3):167-77. PMID 19185668
- Catalano A, Bellone F, Morabito N, et al. Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with Osteoporosis. Nutrients. 2021;13(6):1878. PMID 34072655
Stack Score
How this pair moves the number.
Effect on the composite score
If both Magnesium Glycinate and Medroxyprogesterone are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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