NutriStack
Methylcobalamin and SAMe, a synergy.
SAMe is the universal methyl donor; methylcobalamin supports the methionine cycle that regenerates SAMe.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Methylcobalamin and SAMe
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. SAMe is the universal methyl donor; methylcobalamin supports the methionine cycle that regenerates SAMe.
Mechanism. B12 enables methionine synthase to regenerate methionine, which is then converted to SAMe. Inputs into the methyl pool work synergistically.
Recommendation. Combining supports methylation status, useful in depression and homocysteine management. Pair with methylfolate for full cycle support.
Sources (1)
- Bottiglieri T. S-Adenosyl-L-methionine (SAMe): from the bench to the bedside. Am J Clin Nutr. 2002
Stack Score
How this pair moves the number.
Effect on the composite score
If both Methylcobalamin and SAMe are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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One pair was the worked example. NutriStack runs every pair in your stack at once.
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