NutriStack
Metoprolol and Resveratrol, a synergy.
High-dose resveratrol (≥150 mg/day) modestly reduces systolic blood pressure and improves endothelial function. Combined with metoprolol, the net effect is generally beneficial for vascular health, though additive blood-pressure lowering is possible at higher doses.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Metoprolol and Resveratrol
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. High-dose resveratrol (≥150 mg/day) modestly reduces systolic blood pressure and improves endothelial function. Combined with metoprolol, the net effect is generally beneficial for vascular health, though additive blood-pressure lowering is possible at higher doses.
Mechanism. Resveratrol activates SIRT1 and enhances endothelial nitric oxide synthase activity, improving vasodilation and reducing oxidative stress. These effects complement metoprolol's reduction in cardiac workload.
Recommendation. Resveratrol at typical supplement doses (100-500 mg/day) is generally compatible with metoprolol. Monitor blood pressure when adding higher doses (≥150 mg/day) and tell your prescriber if readings drop below target.
Sources (2)
- Liu Y, Ma W, Zhang P, He S, Huang D. Effect of resveratrol on blood pressure: a meta-analysis of randomized controlled trials. Clin Nutr. 2015;34(1):27-34. PMID 24731650
- Fogacci F, Tocci G, Presta V, Fratter A, Borghi C, Cicero AFG. Effect of resveratrol on blood pressure: A systematic review and meta-analysis of randomized, controlled, clinical trials. Crit Rev Food Sci Nutr. 2019;59(10):1605-1618. PMID 29359958
Stack Score
How this pair moves the number.
Effect on the composite score
If both Metoprolol and Resveratrol are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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