NutriStack
Fluconazole and Resveratrol, a caution.
Resveratrol inhibits CYP3A4 in vitro and in animal pharmacokinetic studies, where it has raised plasma exposure of CYP3A4 substrates such as nicardipine and ticagrelor. Layered on top of fluconazole's CYP3A4 and CYP2C9 inhibition, this could blunt clearance of other prescription medications metabolized by these enzymes.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Fluconazole and Resveratrol
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Resveratrol inhibits CYP3A4 in vitro and in animal pharmacokinetic studies, where it has raised plasma exposure of CYP3A4 substrates such as nicardipine and ticagrelor. Layered on top of fluconazole's CYP3A4 and CYP2C9 inhibition, this could blunt clearance of other prescription medications metabolized by these enzymes.
Mechanism. Resveratrol inhibits CYP3A4, CYP1A and CYP2E1 activities in human liver microsomes and inhibits P-glycoprotein. Combining it with fluconazole produces additive suppression of CYP3A4-mediated metabolism.
Recommendation. Pause resveratrol supplementation during your fluconazole course, particularly if you also take statins, calcium channel blockers, anticoagulants, or benzodiazepines. Resume once fluconazole has cleared.
Sources (2)
- Chan WK, Delucchi AB. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Life Sci. 2001;69(2):85-93. PMID 11701226
- Wang X, et al. Inhibitory effect of resveratrol on the pharmacokinetics of ticagrelor in vivo and in vitro. Pharmacology. 2021. PMID 33400617
Stack Score
How this pair moves the number.
Effect on the composite score
If both Fluconazole and Resveratrol are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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