Interaction databaseSupplement × SupplementReviewed May 2026

Silicon and Vitamin B7, a synergy.

Silicon and biotin (vitamin B7) are commonly combined for hair, skin, and nail support, with silicon supporting collagen and biotin supporting keratin production.

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances
Silicon and Vitamin B7
Pair type
Synergy
Evidence (highest tier)
Emerging
Source citations
2 sources
Stack Score effect
+2 to your Stack Score (per scored synergy row).
Scope
Supplement × Supplement
Last verified
May 30, 2026

Synergy · Emerging evidence

Synergy

What is happening. Silicon and biotin (vitamin B7) are commonly combined for hair, skin, and nail support, with silicon supporting collagen and biotin supporting keratin production.

Mechanism. Silicon supports collagen synthesis and connective tissue structure, while biotin is a cofactor for carboxylase enzymes involved in keratin-related metabolism, addressing different structural proteins.

Recommendation. Reasonable to combine for cosmetic and connective tissue goals at standard doses. Note that controlled human evidence for the specific combination is limited.

Sources (2)
  1. Randomized, Double-Blind, Placebo-Controlled Study of Silica and Biotin Extracts on Hair, Skin and Nail Health, 2024
  2. Barel A et al., Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair, Archives of Dermatological Research, 2005

Stack Score

How this pair moves the number.

Effect on the composite score

If both Silicon and Vitamin B7 are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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